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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Paternal monoallelic expression of the paired immunoglobulin- like receptors PIR-A and PIR-B
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Paternal monoallelic expression of the paired immunoglobulin- like receptors PIR-A and PIR-B

机译：配对的免疫球蛋白样受体PIR-A和PIR-B的父亲单等位基因表达

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摘要

A diverse pattern of polymorphism is defined for the paired Ig-like receptors (PIRs) that serve as activating (PIR-A) and inhibitory (PIR-B) receptors on B lymphocytes, dendritic cells, and myeloid-lineage cells in mice. The mono- clonal anti-PIR antibody 10.4 is shown to recognize an allelic PIR-A/PIR-B determinant on cells from BALB/c but not C57BL/6 mice. Other strains of inbred mice also can be typed on the basis of their expression of this PIR allelic determinant. Analysis of (BALB/c X C57BL/6) F_1 hybrid offspring indi- cates that PIR molecules bearing the paternal PIR allotype are expressed whereas PIR-A and PIR-B molecules bearing the maternal allotype are not. The monoallelic expression of the polymorphic PIR-A and PIR-B molecules, and possibly of their human Ig-like transcript/leukocyte Ig-like receptor/ monocyte/macrophage Ig-like receptor and killer cell inhibi- tory receptor relatives, may influence innate and specific immune responses in outbred populations.
机译：为配对的Ig样受体（PIR）定义了多样化的多态性模式，这些Ig样受体在小鼠中充当B淋巴细胞，树突状细胞和髓系细胞上的激活（PIR-A）和抑制性（PIR-B）受体。已显示单克隆抗PIR抗体10.4识别BALB / c细胞而非C57BL / 6小鼠的等位基因PIR-A / PIR-B决定簇。也可以基于它们的这种PIR等位基因决定簇的表达来对其他近交系小鼠进行分型。对（BALB / c X C57BL / 6）F_1杂交后代的分析表明，表达带有父本PIR同种异型的PIR分子，而不表达带有母本同种异型的PIR-A和PIR-B分子。多态性PIR-A和PIR-B分子的单等位基因表达，以及可能与人Ig样转录物/白细胞Ig样受体/单核细胞/巨噬细胞Ig样受体和杀伤细胞抑制性亲戚的单等位基因表达可能会影响先天性和近亲人群的特异性免疫反应。

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