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首页> 外文期刊>Proceedings of the IEEE >Closed-Loop Neuromodulation Technology for Baroreflex Blood Pressure Control
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Closed-Loop Neuromodulation Technology for Baroreflex Blood Pressure Control

机译：用于压力反射控制的闭环神经调节技术

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摘要

Blood pressure is a vital element to maintain circulation and eventually cellular respiration and metabolism. Blood pressure abnormalities are one of the most common diseases worldwide and their prevalence increases with age. For decades, basic and clinical investigations have shown that autonomic dysregulation/imbalance is involved in the development and progression of cardiovascular diseases. Arterial baroreflex is a powerful regulator of blood pressure and sympathetic nervous system. Closed-loop neuromodulation technology focusing on arterial baroreflex is challenging and might be promising to tackle the pathogenesis of blood pressure-related disorders, autonomic dysregulation, and eventually cardiovascular diseases. For more than a decade, we and associates have developed “bionic” baroreflex systems. “Bionic” means that the device is designed to replicate the dynamic characteristics of the native system to fully restore the function. The bionic baroreflex system basically consists of an artificial pressure sensor, a neurostimulator for autonomic nerves and a regulator that encodes blood pressure into neurostimulation. In the process of development toward clinical applicability, researchers have faced logical problems in designing the controller and practical problems of how to approach baroreflex activation. Closed-loop baroreflex systems utilizing sympathetic nerve trunk stimulation, spinal cord stimulation and noninvasive transcutaneous stimulation were proposed. Recently, the bionic baroreceptor was reported and proposed to be a potential therapy for heart failure. In this article, we introduce the closed-loop neuromodulation technology for baroreflex blood pressure control and discuss future direction of development of this technology.
机译：血压是维持血液循环并最终维持细胞呼吸和新陈代谢的重要因素。血压异常是全世界最常见的疾病之一，其患病率随着年龄的增长而增加。几十年来，基础和临床研究表明，自主神经失调/失衡与心血管疾病的发生和发展有关。动脉压力反射是血压和交感神经系统的强大调节器。专注于动脉压力反射的闭环神经调节技术具有挑战性，可能有望解决与血压有关的疾病，自主神经调节异常以及最终心血管疾病的发病机理。十多年来，我们和员工开发了“仿生”压力反射系统。 “仿生”是指该设备旨在复制本机系统的动态特性以完全恢复功能。仿生压力反射系统主要由一个人造压力传感器，一个用于自主神经的神经刺激器和一个将血压编码为神经刺激的调节器组成。在向临床应用发展的过程中，研究人员在设计控制器时遇到了逻辑问题，以及如何应对压力反射激活的实际问题。提出了利用交感神经干刺激，脊髓刺激和无创经皮刺激的闭环压力反射系统。最近，仿生压力感受器得到了报道，并被提议作为心力衰竭的一种潜在疗法。在本文中，我们介绍了用于压力反射性血压控制的闭环神经调节技术，并讨论了该技术的未来发展方向。

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