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首页> 外文期刊>Proceedings of the IEEE >Simultaneous Molecular and Hypoxia Imaging of Brain Tumors In Vivo Using Spectroscopic Photoacoustic Tomography
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Simultaneous Molecular and Hypoxia Imaging of Brain Tumors In Vivo Using Spectroscopic Photoacoustic Tomography

机译：使用光谱光声层析成像技术对体内脑肿瘤同时进行分子和低氧成像

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摘要

Noninvasive molecular and functional imaging in vivo is promising for detecting and monitoring various physiological conditions in animals and ultimately humans. To this end, we present a novel noninvasive technology, spectroscopic photoacoustic tomography (SPAT), which offers both strong optical absorption contrast and high ultrasonic spatial resolution. Optical contrast allows spectroscopic separation of signal contributions from multiple optical absorbers (e.g., oxyhemoglobin, deoxyhemoglobin, and a molecular contrast agent), thus enabling simultaneous molecular and functional imaging. SPAT successfully imaged with high resolution the distribution of a molecular contrast agent targeting integrin $ alpha_{rm v}beta_{3}$ overexpressed in human U87 glioblastomas in nude mouse brains. Simultaneously, SPAT also imaged the hemoglobin oxygen saturation and the total hemoglobin concentration of the vasculature, which revealed hypoxia in tumor neovasculature. Therefore, SPAT can potentially lead to better understanding of the interrelationships between hemodynamics and specific biomarkers associated with tumor progression.
机译：体内非侵入性分子和功能成像有望用于检测和监测动物乃至人类的各种生理状况。为此，我们提出了一种新颖的非侵入性技术，即光谱光声层析成像（SPAT），它既具有强大的光学吸收对比度，又具有高超声空间分辨率。光学对比度允许从多个光学吸收体（例如氧合血红蛋白，脱氧血红蛋白和分子造影剂）中分离出信号成分，从而实现分子和功能同时成像。 SPAT以高分辨率成功成像了在裸鼠脑中的人U87胶质母细胞瘤中过表达的针对整联蛋白$ alpha_ {rm v} beta_ {3} $的分子造影剂的分布。同时，SPAT还对血红蛋白氧饱和度和脉管系统的总血红蛋白浓度进行了成像，从而揭示了肿瘤新脉管系统的缺氧。因此，SPAT可能会导致更好地了解与肿瘤进展相关的血液动力学和特定生物标志物之间的相互关系。

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