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Modeling Human Physiology: The IUPS/EMBS Physiome Project

机译:建模人类生理学:IUPS / EMBS生理学项目

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摘要

The Physiome Project is an international collaboration to provide a framework for understanding human physiology, from proteins and cells to tissues and organs, with multiscale models that use computational techniques derived from engineering and software approaches from computer science. With the increasing interest in modeling living systems from research scientists in many branches of mathematics, physics, and engineering, it is timely to review what has been achieved, what lessons can be learned from the efforts so far, and what needs to be done to facilitate the international collaboration that is essential to the project's success. In particular, we review the development of models at spatial scales from genes and proteins to the whole body, and the development of standards, tools, and databases to facilitate multiscale modeling. Some applications of the physiome models are described, including applications in medical diagnostics, the design of medical devices, virtual surgery, surgical training, and medical education.
机译:Physiome项目是一项国际合作,旨在提供一个框架,以了解从蛋白质,蛋白质到细胞以及组织和器官的人类生理学,并使用多尺度模型,这些模型使用从工程学和计算机科学的软件方法中获得的计算技术。随着数学,物理学和工程学许多分支领域的研究科学家对生命系统建模的兴趣日益浓厚,现在应该适时地回顾已取得的成就,从迄今为止的努力中可以学到什么教训以及需要做什么。促进对项目成功至关重要的国际合作。特别是,我们回顾了从基因和蛋白质到整个人体的空间尺度模型的发展,以及促进多尺度建模的标准,工具和数据库的发展。描述了物理组模型的一些应用,包括在医疗诊断,医疗设备设计,虚拟手术,外科培训和医学教育中的应用。

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