...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Process Biochemistry >Urinary metabonomics study on the protective effects of ergosta-4,6,8(14),22-tetraen-3-one on chronic renal failure in rats using UPLC Q-TOF/MS and a novel MS~E data collection technique
【24h】

Urinary metabonomics study on the protective effects of ergosta-4,6,8(14),22-tetraen-3-one on chronic renal failure in rats using UPLC Q-TOF/MS and a novel MS~E data collection technique

机译：利用UPLC Q-TOF / MS和新型MS〜E数据采集技术研究泌尿代谢组学对ergosta-4、6、8（14），22-tetraen-3-one对大鼠慢性肾功能衰竭的保护作用

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ergosta-4,6,8(14),22-tetraen-3-one (ergone), isolated from the medicinal fungus Polyporus umbellatus, has been proven to prevent the progression of renal injury and the subsequent renal fibrosis. UPLC Q-TOF/MS was employed to investigate the metabonomic characteristics of adenine-induced chronic renal failure (CRF) and the proactive effects of ergone. The significant difference of the metabolic profiling was observed from ergone-treated group compared with the CRF model group during the 10-day and 20-day study periods by using the principal components analysis (PCA). The significant difference of the ergone-treated group in metabolic profiling was also observed between 10-day and 20-day study periods. The time-dependent tendency in ergone-treated group from day 10 to 20 was obtained, indicating the time-dependent recovery effect of ergone on CRF rats. Some significantly changed metabolites like creatinine, proline, adrenosterone, taurine, creatine, phenylalanine, ornithine, dopamine, kynure-nine, kynurenic acid and 3-O-methyldopa have been identified during the 20-day study period. These biochemical changes are related to the disturbance in energy metabolism and amino acid metabolism, which are helpful to further understand the CRF and the therapeutic mechanism of ergone. This work suggests that this metabonomic approach could be used as a potentially powerful tool to investigate the biochemical changes of certain physiopathological conditions, such as metabolic syndrome, as an early diagnostic measure.
机译：从药用真菌猪Poly多孔菌中分离得到的Ergosta-4,6,8（14），22-tetraen-3-one（ergone）可预防肾损伤的发展和随后的肾纤维化。 UPLC Q-TOF / MS用于研究腺嘌呤诱发的慢性肾衰竭（CRF）的代谢组学特征和麦角酮的积极作用。使用主成分分析（PCA），在10天和20天的研究期内，与CRF模型组相比，麦角酮治疗组与CRF模型组的代谢谱差异显着。在10天至20天的研究期间，也观察到了麦角酮治疗组的代谢谱分析存在显着差异。获得了从第10天到第20天的麦角酮治疗组的时间依赖性趋势，表明麦角酮对CRF大鼠具有时间依赖性的恢复作用。在为期20天的研究期内，已发现一些明显变化的代谢物，例如肌酐，脯氨酸，肾上腺素，牛磺酸，肌酸，苯丙氨酸，鸟氨酸，多巴胺，犬尿蛋白，犬尿酸和3-O-甲基多巴。这些生化变化与能量代谢和氨基酸代谢紊乱有关，有助于进一步了解CRF和麦角酮的治疗机理。这项工作表明，这种代谢组学方法可以作为潜在的强大工具来研究某些生理病理状况（如代谢综合征）的生化变化，并将其作为早期诊断手段。

著录项

  • 来源
    《Process Biochemistry》 |2012年第12期|1980-1987|共8页
  • 作者

    Ying-Yong Zhao; Xuefeng Shen; Xian-Long Cheng; Feng Wei; Xu Bai; Rui-Chao Lin;

  • 作者单位

    Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, the College of Life Sciences, Northwest University, No. 229 Taibai North Road, Xi'an,Shaanxi 710069, China;

    Department of Occupational and Environmental Health, Faculty of Military Preventive Medicine, Fourth Military Medical University, Xi'an, Shaanxi 710032, China;

    National Institutes for Food and Drug Control, State Food and Drug Administration, 2 Tiantan Xili, Beijing 100050, China;

    National Institutes for Food and Drug Control, State Food and Drug Administration, 2 Tiantan Xili, Beijing 100050, China;

    Waters Technologies (Shanghai) Ltd, Shanghai 201203, China;

    National Institutes for Food and Drug Control, State Food and Drug Administration, 2 Tiantan Xili, Beijing 100050, China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    metabonomics; chronic renal failure; ergosta-4,6,8(14),22-tetraen-3-one; polyporus umbellatus; ultra performance liquid chromatography; MSE;

    机译：代谢组学慢性肾功能衰竭;ergosta-4,6,8（14）;22-tetraen-3-one;猪超高效液相色谱;微软;

相似文献

  • 外文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号