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首页> 外文期刊>Progress in Materials Science >Modular fabrication of intelligent material-tissue interfaces for bioinspired and biomimetic devices
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Modular fabrication of intelligent material-tissue interfaces for bioinspired and biomimetic devices

机译：用于仿生和仿生设备的智能材料-组织界面的模块化制造

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摘要

One of the goals of biomaterials science is to reverse engineer aspects of human and non-human physiology. Similar to the body's regulatory mechanisms, such devices must transduce changes in the physiological environment or the presence of an external stimulus into a detectable or therapeutic response. This review is a comprehensive evaluation and critical analysis of the design and fabrication of environmentally responsive cell-material constructs for bioinspired machinery and biomimetic devices. In a bottom-up analysis, we begin by reviewing fundamental principles that explain materials' responses to chemical gradients, biomarkers, electromagnetic fields, light, and temperature. Strategies for fabricating highly ordered assemblies of material components at the nano to macro-scales via directed assembly, lithography, 3D printing and 4D printing are also presented. We conclude with an account of contemporary material-tissue interfaces within bioinspired and biomimetic devices for peptide delivery, cancer theranostics, biomonitoring, neuroprosthetics, soft robotics, and biological machines.
机译：生物材料科学的目标之一是对人类和非人类生理学进行逆向工程。类似于人体的调节机制，此类设备必须将生理环境的变化或外部刺激的存在转化为可检测的或治疗的反应。这篇评论是对生物启发性机械和仿生设备的环境响应性细胞材料构造的设计和制造的全面评估和关键分析。在自下而上的分析中，我们首先回顾解释材料对化学梯度，生物标记，电磁场，光和温度的反应的基本原理。还提出了通过定向组装，光刻，3D打印和4D打印在纳米到宏观尺度上制造高度有序的材料组件的策略。我们以生物启发和仿生设备中用于肽传递，癌症治疗学，生物监测，神经修复，软机器人和生物机器的当代材料-组织界面作为总结。

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  • 来源
    《Progress in Materials Science》 |2019年第12期|100589.1-100589.73|共73页
  • 作者

    Clegg John R.; Wagner Angela M.; Shin Su Ryon; Hassan Shabir; Khademhosseini Ali; Peppas Nicholas A.;

  • 作者单位

    Univ Texas Austin Dept Biomed Engn Austin TX 78712 USA;

    Univ Texas Austin McKetta Dept Chem Engn Austin TX 78712 USA;

    Harvard Med Sch Brigham Womens Hosp Dept Med Div Engn Med Cambridge MA USA;

    Harvard Med Sch Brigham Womens Hosp Dept Med Div Engn Med Cambridge MA USA|MIT Harvard Mit Div Hlth Sci & Technol Cambridge MA 02139 USA;

    Univ Calif Los Angeles C MIT Los Angeles CA 90095 USA|Univ Calif Los Angeles Calif NanoSyst Inst CNSI Los Angeles CA 90095 USA|Univ Calif Los Angeles Dept Bioengn Los Angeles CA 90095 USA;

    Univ Texas Austin Dept Biomed Engn Austin TX 78712 USA|Univ Texas Austin McKetta Dept Chem Engn Austin TX 78712 USA|Univ Texas Austin Inst Biomat Drug Delivery & Regenerat Med Austin TX 78712 USA|Univ Texas Austin Dell Med Sch Dept Surg & Perioperat Care Austin TX 78712 USA|Univ Texas Austin Dell Med Sch Dept Pediat Austin TX 78712 USA|Univ Texas Austin Coll Pharm Div Mol Pharmaceut & Drug Delivery Austin TX 78712 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Cell-material constructs; Biofabrication; Bioprinting; Biomimetic materials; Intelligent hydrogels; Molecular machines; Drug delivery; Theranostics; Tissue engineering;

    机译：细胞材料构造;生物制造;生物印刷;仿生材料;智能水凝胶;分子机器;药物输送;治疗学;组织工程;

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