...
首页> 外文期刊>Psychiatry >Association Between COMT, PTSD, and Increased Smoking Following Hurricane Exposure in an Epidemiologic Sample
【24h】

Association Between COMT, PTSD, and Increased Smoking Following Hurricane Exposure in an Epidemiologic Sample

机译:在流行病学样本中,COMT,PTSD与飓风暴露后吸烟增加之间的关联

获取原文
获取原文并翻译 | 示例
           

摘要

Tobacco smoking has been found to increase after the experience of a traumatic event and has been associated with posttraumatic stress disorder (PTSD). Initiation and persistence of cigarette smoking is moderately heritable; two recent investigations have implicated the COMT Val158Met (also known as rs4680) polymorphism in smoking age of initiation, dependence, as well as in quantity and frequency of smoking. To examine a possible association of COMT Val158Met and posttrauma increases in cigarette smoking, we studied 614 adults from the 2004 Florida Hurricane Study who returned saliva DNA samples via mail. PTSD was strongly associated with increased smoking. Moreover, each COMT Val158Met 'Met' allele predicted a 2.10-fold risk of smoking post-hurricane, independent of PTSD; follow-up analyses revealed that this finding was primarily driven by European-American males. This study represents the first genetic association study (to our knowledge) of smoking behavior following an acute stressor. [PUBLICATION ABSTRACT]
机译:已经发现在经历创伤事件后吸烟增加,并且与创伤后应激障碍(PTSD)有关。吸烟的起因和持续性是中度遗传的;最近的两项研究表明,COMT Val158Met(也称为rs4680)多态性与吸烟的起始年龄,依赖性,吸烟的数量和频率有关。为了研究COMT Val158Met和创伤后吸烟增加的可能联系,我们研究了2004年佛罗里达飓风研究中的614名成年人,他们通过邮件返回了唾液DNA样本。 PTSD与吸烟增加密切相关。此外,每个COMT Val158Met'Met'等位基因预测的飓风后吸烟风险为2.10倍,而与PTSD无关。后续分析显示,这一发现主要是由欧美男性推动的。这项研究是(据我们所知)关于急性应激后吸烟行为的第一个遗传关联研究。 [出版物摘要]

著录项

  • 来源
    《Psychiatry》 |2009年第4期|p.360-369|共10页
  • 作者单位

    Ananda B. Amstadter, PhD, Kenneth J. Ruggiero, PhD, Ron Acierno, PhD, and Dean G. Kilpatrick, PhD, are affiliated with the Department of Psychiatry and Behavioral Science, Medical University of South Carolina in Charleston. Nicole R. Nugent, PhD, is with the Bradley/Hasbro Children's Research Center, Brown Medical School, in Providence, Rhode Island. Karestan C. Koenen, PhD, is with the Departments of Society, Human Development, and Health 6c Epidemiology at the Harvard School of Public Health in Boston. Sandro Galea, MD, MPH, DrPH, is with the University of Michigan Center for Social Epidemiology and Population Health in Ann Arbor, Michigan. Joel Gelernter, MD, is affiliated with the Departments of Psychiatry, Genetics, and Neurobiology, Yale University School of Medicine, New Haven, Connecticut.This research was supported by NIMH grant MH05220, NIMH and NIN research grant MH07055, and NIDA grants K24 DA15105, ROl DA12690, and ROl DA12849. Dr. Amstadter is supported by NIMH grant 18869. Dr. Koenen is supported by NIMH grants K08-MH070627 and MH078928.The authors declare no conflicting financial or other competing interests.Address correspondence to Ananda B. Amstadter, PhD, Department of Psychiatry and Behavioral Science, Medical University of South Carolina, 67 President Street, 2-S, Charleston, SC 29425, E-mail: amstadt@musc.edu,;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号