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Enhanced emotion-induced amnesia in borderline personality disorder

机译：边缘型人格障碍中情绪诱发的健忘症的增强

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Background. Current biological concepts of borderline personality disorder (BPD) emphasize the interference of emotional hyperarousal and cognitive functions. A prototypical example is episodic memory. Pre-clinical investigations of emotion-episodic memory interactions have shown specific retrograde and anterograde episodic memory changes in response to emotional stimuli. These changes are amygdala dependent and vary as a function of emotional arousal and valence. Method. To determine whether there is amygdala hyper-responsiveness to emotional stimuli as the underlying pathological substrate of cognitive dysfunction in BPD, 16 unmedicated female patients with BPD were tested on the behavioural indices of emotion-induced amnesia and hypermnesia established in 16 healthy controls. Results. BPD patients displayed enhanced retrograde and anterograde amnesia in response to presentation of negative stimuli, while positive stimuli elicited no episodic memory-modulating effects. Conclusion. These findings suggest that an amygdala hyper-responsiveness to negative stimuli may serve as a crucial aetiological contributor to emotion-induced cognitive dysfunction in BPD.
机译：背景。边缘人格障碍（BPD）的当前生物学概念强调情绪亢奋和认知功能的干扰。一个典型的例子是情节记忆。临床上对情绪-发作性记忆相互作用的研究表明，特定的逆行和顺行性发作性记忆变化是对情绪刺激的反应。这些变化是杏仁核依赖性的，并且根据情绪唤醒和化合价而变化。方法。为了确定杏仁核对情绪刺激是否具有超敏反应作为BPD认知功能障碍的潜在病理学基础，我们对16名健康对照中建立的16名未经药物治疗的女性BPD患者进行了情绪诱发的健忘和高健的行为指标测试。结果。 BPD患者在出现负刺激时表现出增强的逆行和顺行性健忘症，而正刺激则无发作性记忆调节作用。结论。这些发现表明杏仁核对负刺激的过度反应可能是BPD情绪诱发的认知功能障碍的重要病因。

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