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首页> 外文期刊>Psychological medicine >Mild cognitive impairment: applicability of research criteria in a memory clinic and characterization of cognitive profile.
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Mild cognitive impairment: applicability of research criteria in a memory clinic and characterization of cognitive profile.

机译：轻度认知障碍：研究标准在记忆临床中的适用性和认知特征的表征。

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BACKGROUND: We explored the applicability of recently proposed research criteria for mild cognitive impairment (MCI) in a memory clinic and changes in case definition related to which memory tests are used and the status of general cognitive function in MCI. METHOD: A total of 166 consecutive GP referrals to the Cambridge Memory Clinic underwent comprehensive neuropsychological and psychiatric evaluation. RESULTS: Of 166 cases, 42 were excluded (significant depression 8, established dementia 29 and other disorders 5). Of 124 non-demented, non-depressed patients, 72 fulfilled Petersen's criteria for amnestic MCI based upon verbal memory performance [the Rey Auditory Verbal Learning Test (RAVLT)] and 90 met criteria if performance on verbal and/or non-verbal memory tests [the Rey figure recall or the Paired Associates Learning test (PAL)] was considered. Of the 90 broadly defined MCI cases, only 25 had pure amnesia: other subtle semantic and/or attention deficits were typically present. A further 12 were classed as non-amnestic MCI and 22 as 'worried well'. CONCLUSIONS: Definition of MCI varies considerably dependent upon the tests used for case definition. The majority have other cognitive deficits despite normal performance on the Mini-mental State Examination (MMSE) and intact activities of daily living (ADL) and fit within multi-domain MCI. Pure amnesic MCI is rare.
机译：背景：我们探讨了最近提出的针对轻度认知障碍（MCI）的研究标准在记忆诊所中的适用性，以及与使用哪种记忆测试有关的病例定义的变化以及MCI中一般认知功能的状态。方法：总共166个连续GP转诊至Cambridge Memory Clinic接受了全面的神经心理学和精神病学评估。结果：在166例病例中，有42例被排除在外（严重抑郁症8例，痴呆症29例，其他疾病5例）。在124名无痴呆，无抑郁的患者中，有72名基于言语记忆表现[彼得·雷迪听觉语言学习测验（RAVLT）]满足了彼得森记忆删除MCI的标准，如果在言语和/或非言语记忆测试中表现符合，则满足90项标准[考虑了Rey人物召回或配对学习测试（PAL）]。在90例定义广泛的MCI病例中，只有25例纯属健忘症：通常还存在其他细微的语义和/或注意缺陷。另有12个分类为非记忆MCI，另外22个分类为“担心”。结论：MCI的定义在很大程度上取决于案例定义所使用的测试。尽管在迷你智力状态考试（MMSE）上表现正常，并且在日常生活中的完整活动（ADL）上表现良好，但大多数人仍存在其他认知缺陷，并且适合多领域MCI。纯记忆删除MCI很少。

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