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首页> 外文期刊>Psychological medicine >Brain MRI abnormalities in schizophrenia: same genes or same environment?
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Brain MRI abnormalities in schizophrenia: same genes or same environment?

机译：精神分裂症的脑部MRI异常：相同的基因还是相同的环境？

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background. structural brain volume abnormalities are among the most extensively studied endophenotypes in schizophrenia. bivariate genetic model fitting (adjusted to account for selection) was used to quantify the genetic relationship between schizophrenia and brain volumes and to estimate the heritability of these volumes. method. we demonstrated by simulation that the adjusted genetic model produced unbiased estimates for endophenotype heritability and the genetic and environmental correlations. the model was applied to brain volumes (whole brain, hippocampus, third and lateral ventricles) in a sample of 14 monozygotic (mz) twin pairs concordant for schizophrenia, 10 mz discordant pairs, 17 mz control pairs, 22 discordant sibling pairs, three concordant sibling pairs, and 114 healthy control subjects. results. whole brain showed a substantial heritability (88%) and lateral ventricles substantial common environmental effects (67%). whole brain showed a significant genetic correlation with schizophrenia, whereas lateral ventricles showed a significant individual specific correlation with schizophrenia. there were significant familial effects for hippocampus and third ventricle, but the analyses could not resolve whether these were genetic or environmental in origin (around 30% each). conclusions. using genetic model fitting on twin and sibling data we have demonstrated differential sources of covariation between schizophrenia and brain volumes, genetic in the case of whole brain volume and individual specific environment in the case of lateral ventricles.
机译：背景。结构性脑容量异常是精神分裂症中研究最广泛的内表型之一。使用双变量遗传模型拟合（调整以考虑选择）来量化精神分裂症和脑容量之间的遗传关系，并估计这些容量的遗传力。方法。我们通过仿真证明，调整后的遗传模型对内表型遗传力以及遗传和环境相关性产生了无偏估计。将模型应用于精神分裂症的14个单卵双胎（mz）双胞胎对，10 mz不一致对，17 mz对照对，22个不一致兄弟对，三个一致脑的体积（整个脑，海马，第三侧脑和外侧脑室）同胞对和114个健康对照对象。结果。全脑显示出显着的遗传力（88％），侧脑室产生了常见的常见环境影响（67％）。全脑显示出与精神分裂症的显着遗传相关性，而侧脑室显示出与精神分裂症的显着的个体特异性相关性。对海马和第三脑室有明显的家族效应，但分析无法确定它们是遗传的还是环境起源的（每个约占30％）。结论。使用对双胞胎和同胞数据进行拟合的遗传模型，我们证明了精神分裂症和脑容量之间协变的差异来源，对于全脑容量而言是遗传的，而对于侧脑室来说则是个体特定的环境。

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