MD-354 selectively antagonizes the antinociceptive effects of (−)nicotine in the mouse tail-flick assay

Małgorzata Dukat; Anna Wesołowska; Genevieve Alley; Shawquia Young; Galya R. Abdrakhmanova; Hernán A. Navarro; Richard Young; Richard A. Glennon

首页> 外文期刊>Psychopharmacology >MD-354 selectively antagonizes the antinociceptive effects of (−)nicotine in the mouse tail-flick assay

【24h】

MD-354 selectively antagonizes the antinociceptive effects of (−)nicotine in the mouse tail-flick assay

机译：MD-354在小鼠甩尾试验中选择性拮抗（-）烟碱的镇痛作用

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Rationale (−)Nicotine produces antinociceptive effects in rodents. meta-Chlorophenylguanidine (MD-354), an analgesia-enhancing agent, binds at 5-HT₃ and α₂-adrenoceptors and potentiates the antinociceptive effects of an “inactive” dose of clonidine. The present study examined the actions of MD-354 on (−)nicotine-induced antinociception.

机译：原理（-）尼古丁可在啮齿动物中产生抗伤害感受作用。间氯苯胍（MD-354）是一种止痛增强剂，与5-HT _{3 和α_{2 肾上腺素能受体结合并增强“非活性”药物的镇痛作用可乐定的剂量。本研究检查了MD-354对（-）烟碱诱导的抗伤害感受的作用。}}

著录项

来源
《Psychopharmacology》 |2010年第4期|p.547-557|共11页
作者
Małgorzata Dukat; Anna Wesołowska; Genevieve Alley; Shawquia Young; Galya R. Abdrakhmanova; Hernán A. Navarro; Richard Young; Richard A. Glennon;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词
Behavioral assays; Mice; Rats; Antinociception; (−)Nicotine; MD; 354; Drug discrimination; α7 nACh receptors; Negative allosteric modultor;

机译：行为分析;老鼠;大鼠;抗伤害感受;（-）尼古丁MD;354;毒品歧视;α7nACh受体;负变构调节剂;

相似文献

外文文献
中文文献
专利

1. MD-354 selectively antagonizes the antinociceptive effects of (-)nicotine in the mouse tail-flick assay. [J] . Dukat M, Wesolowska A, Alley G, Psychopharmacology . 2010,第4期

机译：MD-354在小鼠甩尾试验中选择性拮抗（-）烟碱的镇痛作用。
2. MD-354 potentiates the antinociceptive effect of clonidine in the mouse tail-flick but not hot-plate assay. [J] . Wesolowska A, Young S, Dukat M European Journal of Pharmacology: An International Journal . 2004,第2a3期

机译：MD-354增强了可乐定在小鼠甩尾实验中的镇痛作用，但不能增强热板试验的镇痛作用。
3. Associative and behavioral tolerance to the analgesic effects of nicotine in rats: tail-flick and paw-lick assays [J] . Antonio Cepeda-Benito, Kristina W. Davis, Jose T. Reynoso, Psychopharmacology . 2005,第2期

机译：尼古丁对大鼠镇痛作用的联合和行为耐受性：甩尾和舔爪试验
4. TEA EXTRACTS CONFER ITS ANTIPROLIFERATING EFFECTS THROUGH INHIBITION OF NICOTINE- AND ESTROGEN-INDUCED 9-NICOTINIC ACETYLCHOLINE RECEPTOR UPREGULATION IN HUMAN BREAST CANCER CELLS [C] . Yuan-Soon Ho, Min-Hsiung Pan International Flavor Conference . 2013

机译：茶提取物通过抑制尼古丁和雌激素诱导的9-烟碱乙酰胆碱受体上调在人乳腺癌细胞中赋予其抗增殖效果
5. Effects of Knocking Out RIC3 and TMEM35 Chaperones on ALPHA7 Nicotinic Receptor Receptors in Mouse Brains [D] . Deshpande, Anish R. 2020

机译：敲除RIC3和TMEM35伴侣在小鼠脑中α7烟碱受体受体受体受体的影响
6. Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment. [O] . S M Crain, K F Shen 1995

机译：超低浓度的纳洛酮可选择性拮抗吗啡对感觉神经元的兴奋作用从而增加其抗伤害感受力并减弱慢性共治疗期间的耐受性/依赖性。
7. Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreatment. [O] . Crain, S M, Shen, K F 1995

机译：超低浓度的纳洛酮可选择性拮抗吗啡对感觉神经元的兴奋作用，从而增加其抗伤害感受力并减弱慢性共治疗期间的耐受性/依赖性。

MD-354 selectively antagonizes the antinociceptive effects of (−)nicotine in the mouse tail-flick assay

摘要

著录项

相似文献

相关主题

期刊订阅