Innovating Openly: Researchers and Patients Turn to Crowdsourcing to Collaborate on Clinical Trials, Drug Discovery, and More

Cruzan Morton C.

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Innovating Openly: Researchers and Patients Turn to Crowdsourcing to Collaborate on Clinical Trials, Drug Discovery, and More

机译：公开创新：研究人员和患者转向众包进行临床试验，药物发现等方面的合作

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several years ago, Stanford University researchers stumbled across something unexpected. In the course of examining the autopsied brain tissue of people with multiple sclerosis (MS), a team in Lawrence Steinman?s laboratory noticed significantly elevated levels of angiotensin enzymes and receptors, better known for their role in hypertension. This led them to believe that perhaps an angiotensin inhibitor, such as lisinopril, a common, inexpensive, and relatively safe high blood pressure medication, might effectively reduce the damaging flareups of MS. In fact, when they administered the drug to mice crippled by MS-like inflammatory nerve damage, it reversed their paralysis.

机译：几年前，斯坦福大学的研究人员偶然发现了一些意外情况。在检查患有多发性硬化症（MS）的人的尸体脑组织的过程中，劳伦斯·斯坦曼实验室的一个研究小组发现，血管紧张素酶和受体的水平显着升高，以其在高血压中的作用而闻名。这使他们相信也许是一种血管紧张素抑制剂，例如赖诺普利，一种常见，便宜且相对安全的高血压药物，可以有效减少MS的破坏性发作。实际上，当他们向因MS样炎性神经损伤而瘫痪的老鼠服用这种药物时，它可以扭转它们的瘫痪状态。

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《Pulse, IEEE》 |2014年第1期|63-67|共5页
作者
Cruzan Morton C.;
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Multiple Sclerosis Discovery Forum, Piscataway, NJ 08854 USA|c|;

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4. Patient in control in clinical trials - European initiatives for improving patient empowerment in clinical trials through technical implementation of legal norms [C] . Forgo Nikolaus, Goralczyk Magdalena, Hanold Stefanie Annual Conference of Japanese Society for Medical and Biological Engineering;Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2013

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6. Perspectives of the Working Group on Drug Trials including Collaborative Trials of the ISBD and rationale for new clinical trials [O] . S Assaad-Khalil 2003

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7. India's Clinical Trial Regulatory Changes, Indian Researcher?s Awareness of Recently Changed Regulations, and the Impact of the New Drugs and Clinical Trial Rules: A Review [O] . V. VENNU, P. P. SAINI 2020

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Innovating Openly: Researchers and Patients Turn to Crowdsourcing to Collaborate on Clinical Trials, Drug Discovery, and More

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