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首页> 外文期刊>Quality of Life Research >Quality of life of nasopharyngeal carcinoma survivors in Mainland China
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Quality of life of nasopharyngeal carcinoma survivors in Mainland China

机译：中国大陆鼻咽癌幸存者的生活质量

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摘要

The aim of this study is to evaluate the quality of life (QoL) of nasopharyngeal carcinoma (NPC) survivors. 192 NPC survivors treated in 1999 and 2000 were enrolled in this study. Median follow up was 3.6 years (range 2.4–4.6 years). The Chinese SF-36 questionnaire and a self-reported symptom checklist consisting of 14 items were completed at clinics. Sociodemographic factors and clinical information were also collected. Most functional domains of the Chinese SF-36 were significantly worse in NPC survivors compared to the normal population. Xerostomia, hearing loss, hypomnesia, dysphagia, and trismus were frequently reported symptoms. Sociodemographic variables including gender, age, dialect, educational level, monthly income, economic status, and number of comorbidities were univariate predictors of different SF-36 domains and symptoms. Patients with earlier T and N stage, irradiated by linear accelerator, with lower dose and weekly dose to nasopharynx and neck, and those who had anterior nasal radiation field reported better QoL. Multiple stepwise regression analysis showed that the number of comorbidities, monthly income, age, and T stage were independent factors affecting global QoL. We concluded that NPC survivors had worse QoL than the normal population and improving radiotherapy might increase physical and functional domain of QoL.
机译：这项研究的目的是评估鼻咽癌（NPC）幸存者的生活质量（QoL）。这项研究招募了192位在1999年和2000年接受治疗的NPC幸存者。中位随访时间为3.6年（范围2.4-4.6年）。在诊所完成了中文SF-36问卷和一份由14个项目组成的自我报告症状清单。还收集了社会人口统计学因素和临床信息。与正常人群相比，NPC幸存者中中国SF-36的大多数功能域明显更差。口干，听力下降，记忆力减退，吞咽困难和三头肌经常被报告为症状。社会人口统计学变量包括性别，年龄，方言，教育程度，月收入，经济状况和合并症数量是不同SF-36域和症状的单变量预测因子。线性加速器照射的T和N阶段较早的患者，鼻咽和颈部的剂量和每周剂量较低，鼻前辐射场的患者的QoL较好。多元逐步回归分析表明，合并症的数量，月收入，年龄和T分期是影响全球生活质量的独立因素。我们得出的结论是，NPC幸存者的QoL比正常人群差，并且改善放疗可能会增加QoL的身体和功能范围。

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  • 来源
    《Quality of Life Research》 |2007年第1期|65-74|共10页
  • 作者

    Yong Wu; Wei-Han Hu; Yun-Fei Xia; Jun Ma; Meng-Zhong Liu; Nian-Ji Cui;

  • 作者单位

    Department of Oncology First Municipal People’s Hospital of Guangzhou Guangzhou Medical College Guangzhou People’s Republic of China;

    Department of Radiation Oncology Cancer Center and State Key Laboratory of Oncology in Southern China Sun Yat-sen University 651 DongFeng Road East Guangzhou 510060 People’s Republic of China;

    Department of Radiation Oncology Cancer Center and State Key Laboratory of Oncology in Southern China Sun Yat-sen University 651 DongFeng Road East Guangzhou 510060 People’s Republic of China;

    Department of Radiation Oncology Cancer Center and State Key Laboratory of Oncology in Southern China Sun Yat-sen University 651 DongFeng Road East Guangzhou 510060 People’s Republic of China;

    Department of Radiation Oncology Cancer Center and State Key Laboratory of Oncology in Southern China Sun Yat-sen University 651 DongFeng Road East Guangzhou 510060 People’s Republic of China;

    Department of Radiation Oncology Cancer Center and State Key Laboratory of Oncology in Southern China Sun Yat-sen University 651 DongFeng Road East Guangzhou 510060 People’s Republic of China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Chinese SF-36; Nasopharyngeal carcinoma; Quality of life; Radiotherapy;

    机译：SF-36;鼻咽癌;生活质量;放射治疗;

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