...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Quality of Life Research >Health-related Quality of Life in Multiple Sclerosis: The Impact of Disability, Gender and Employment Status
【24h】

Health-related Quality of Life in Multiple Sclerosis: The Impact of Disability, Gender and Employment Status

机译：多发性硬化症中与健康有关的生活质量：残疾，性别和就业状况的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Objectives: (1) Evaluate the impact of the patient charateristics of disability, gender and employment status on health-related quality of life (HRQOL) in multiple sclerosis (MS) and (2) Characterize the functional relationship between HRQOL and disability overall, and by gender and employment status. Methods: We assessed the HRQOL of 215 MS outpatients in our clinic using the MSQOL-54 and Fatigue Severity Scale (FSS), and that of 172 healthy controls, using the SF-36 (a subset of MSQOL-54). We compared QOL between MS subgroups defined by disability, gender and employment, and computed the linear and non-linear relationships between disability level measured by the Expanded Disability Status Scale (EDSS) and MSQOL-54 dimensions. Results: QOL of MS patients measured by SF-36 is lower than controls, varying by QOL dimension with the greatest difference emerging for physical aspects of the disease. The relationship of physical disability, measured by EDSS, and all 14 MSQOL-54 dimensions and FSS is negative; for 12 of the 14 dimensions and FSS it is also non-linear. Non-linearity is most pronounced among women, who show a weak EDSS/QOL relatioship at higher levels of physical disability, suggesting women better able to “psychologically buffer” the debilitating aspects of MS. While employed have higher QOL than unemployed, the former are more affected by physical disability. Conclusions: Multiple attributes, including disability, gender and employment status, affect QOL. QOL’s relationship with disability is complex, displaying non-linearity and interacting with patient characteristics. This has implication for QOL research methodology and provides insight into factors affecting patients’ perceptions of well-being.
机译：目标：（1）评估残疾，性别和就业状况患者特征对多发性硬化症（MS）中与健康相关的生活质量（HRQOL）的影响，以及（2）表征HRQOL与整体残疾之间的功能关系，以及性别和就业状况。方法：我们使用MSQOL-54和疲劳严重程度量表（FSS）评估了我们诊所的215名门诊患者的HRQOL，并使用SF-36（MSQOL-54的子集）评估了172名健康对照者的HRQOL。我们比较了由残疾，性别和就业定义的MS亚组之间的QOL，并计算了由扩展残疾状况量表（EDSS）和MSQOL-54维度衡量的残疾水平之间的线性和非线性关系。结果：通过SF-36测量的MS患者的QOL低于对照组，随QOL尺寸而变化，最大的差异出现在疾病的物理方面。通过EDSS以及所有14个MSQOL-54尺寸和FSS测得的身体残疾之间的关系为负；对于14个维度中的12个和FSS，它也是非线性的。非线性在女性中最为明显，女性在较高的身体残疾水平下表现出较弱的EDSS / QOL关系，这表明女性能够更好地“心理缓冲” MS令人衰弱的方面。尽管受雇者的生活质量比失业者高，但前者受身体残疾的影响更大。结论：包括残疾，性别和就业状况在内的多种属性影响生活质量。 QOL与残疾的关系很复杂，表现出非线性并与患者特征相互作用。这对QOL研究方法具有重要意义，并有助于深入了解影响患者对幸福感的看法的因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号