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首页> 外文期刊>Quality of Life Research >Variations in Self-Rated Health Among Patients with HIV Infection
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Variations in Self-Rated Health Among Patients with HIV Infection

机译：HIV感染患者自我评价健康状况的变化

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摘要

Purpose:To assess how patients with HIV who are enrolled in a clinical trials cohort rate their health and to compare their ratings with those of patients with HIV from 2 other cohorts: the HIV Cost and Services Utilization Study (HCSUS), and Adult AIDS Clinical Trials Group protocol 320 (ACTG 320). Methods: We analyzed baseline information for the 1649 subjects enrolled in the Adult AIDS Clinical Trials Group Longitudinal Linked Randomized Trials (ALLRT) study prior to March 2002 who had self-rated health data available. We compared those results with results from 2 other groups: HCSUS, the only nationally representative sample of people in care for HIV in the U.S., which conducted baseline interviews in 1996 and 1997, and ACTG 320, a randomized, double-blinded, placebo-controlled trial comparing a 3-drug antiretroviral regimen with a 2-drug combination, which enrolled subjects in the same general time frame as HCSUS. We used t tests, Pearson correlations, and linear regression to determine factors associated with self-rated health and z scores to compare results between cohorts. Results: The mean (SD) rating scale value on a 0–100 scale for ALLRT participants was 79.8 (16.8). Values were significantly lower for subjects who were older, had a history of injection drug use, had lower CD4 cell counts, or were beginning salvage antiretroviral therapy. Subjects in ALLRT reported significantly better self-rated health at baseline than those in HCSUS or ACTG 320 (11–12% higher rating scale values in ALLRT; p<0.05). When cohort differences were accounted for through regression and stratification, the differences in scores between subjects in ALLRT and HCSUS increased and the differences in scores between subjects in ALLRT and ACTG 320 diminished. Conclusions: Self-rated health varied significantly by age, CD4 count, injection drug use history, and salvage therapy status. Differences in self-rated health for clinical trials and non-clinical trials samples appear to be substantial and should be considered when applying trial results to clinical populations.
机译：目的：评估参加临床试验的艾滋病病毒感染者队列的健康状况，并将其与其他两个队列的艾滋病毒患者的评级进行比较：“艾滋病毒成本和服务利用研究”（HCSUS）和“成人艾滋病临床”试用组协议320（ACTG 320）。方法：我们分析了2002年3月之前参加成人AIDS临床试验组纵向链接随机试验（ALLRT）研究的1649名受试者的基线信息，这些受试者具有可自我评估的健康数据。我们将这些结果与其他两组的结果进行了比较：HCSUS是美国唯一的全国代表性艾滋病毒感染人群，它在1996年和1997年进行了基线访谈，而ACTG 320是随机，双盲，安慰剂治疗组。对照试验比较了3种药物的抗逆转录病毒疗法和2种药物的组合，该研究纳入了与HCSUS相同的一般时间范围的受试者。我们使用t检验，Pearson相关性和线性回归来确定与自我评估的健康状况相关的因素和z评分，以比较各组之间的结果。结果：ALLRT参与者在0–100量表上的平均（SD）评分量表值为79.8（16.8）。对于年龄较大，有注射毒品史，CD4细胞计数较低或开始抢救抗逆转录病毒疗法的受试者，其值明显较低。与HCSUS或ACTG 320相比，ALLRT的受试者在基线时的自我评估健康状况明显好得多（ALLRT的评估量表值高11–12％； p <0.05）。当通过回归和分层考虑队列差异时，ALLRT和HCSUS中受试者之间的得分差异增加，而ALLRT和ACTG 320中受试者之间的得分差异减小。结论：根据年龄，CD4计数，注射药物使用史和抢救治疗状态，自我评估的健康状况差异显着。临床试验和非临床试验样品在自我评估健康方面的差异似乎很大，应在将试验结果应用于临床人群时予以考虑。

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  • 来源
    《Quality of Life Research》 |2006年第3期|503-514|共12页
  • 作者

    Joseph M. Mrus; Bruce R. Schackman; Albert W. Wu; Kenneth A. Freedberg; Joel Tsevat; Michael S. Yi; Robert Zackin;

  • 作者单位

    Health Services Research ampamp Development Cincinnati VA Medical Center Cincinnati OH;

    Department of Public Health Weill Medical College of Cornell University USA;

    Departments of Health Policy and Management and Medicine The Johns Hopkins University Baltimore MD;

    Division of General Medicine and Partners AIDS Research Center Massachusetts General Hospital Harvard Medical School Boston MA;

    Health Services Research ampamp Development Cincinnati VA Medical Center Cincinnati OH;

    Department of Internal Medicine and Institute for the Study Health University of Cincinnati Medical Center Cincinnati OH;

    Center for Biostatistics in AIDS Research Harvard School of Public Health Boston MA USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    AIDS; Clinical trials; HIV; Quality of life;

    机译：艾滋病;临床试验;艾滋病毒;生活质量;

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