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首页> 外文期刊>Quality of Life Research >The Natural Progression of Health-Related Quality of Life: Results of a Five-Year Prospective Study of SF-36 Scores in a Normative Population
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The Natural Progression of Health-Related Quality of Life: Results of a Five-Year Prospective Study of SF-36 Scores in a Normative Population

机译：与健康有关的生活质量的自然发展：规范人群中SF-36得分的五年前瞻性研究结果

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摘要

Background: Limited information exists regarding the natural progression of health-related quality of life (HRQOL) in the general population, as most research has been cross-sectional or has followed populations with specific medical conditions. Such norms are important to establish, because the effect of any intervention may be confounded by changes due to the natural progression of HRQOL over time. Methods: Participants were randomly selected from 9 Canadian cities and surrounding rural areas. Changes in the eight domains and 2 summary component scores of the Medical Outcomes Study 36-item short form (SF-36) were examined over a 5 year period (1996/1997–2001/2002). Mean changes were calculated for men and women within 10 year age categories. Multiple imputation was used to adjust for potential selection bias due to missing data. Results: The baseline sample included 6539 women and 2884 men. Loss to follow-up was 17% for women and 23% for men. Mean changes tended to be small, but there was an overall trend towards decreasing HRQOL over time. Changes were more pronounced in the older age groups and in the physically oriented domains. Younger age groups tended towards small mean improvements, particularly in the mentally oriented domains. Large standard errors suggest that on an individual level, large improvements in some participants are balanced by large declines in others. Conclusion: In general, the HRQOL of Canadians appears relatively stable over a 5 year period. However, care should be taken when assessing HRQOL longitudinally in certain age or gender groups, as changes associated with an intervention can potentially be confounded by the natural progression of HRQOL.
机译：背景：由于大多数研究是横断面的或针对具有特定医学状况的人群，因此有关普通人群中与健康相关的生活质量（HRQOL）的自然进展的信息有限。建立此类规范很重要，因为任何干预的效果都可能因HRQOL随着时间的自然发展而发生变化而混淆。方法：从加拿大9个城市和周边农村地区随机选择参与者。在5年内（1996 / 1997-2001 / 2002）检查了医学成果研究36项简短形式（SF-36）的8个领域和2个摘要成分得分的变化。计算了10岁以下年龄段男女的平均变化。由于缺少数据，多次插补用于调整潜在的选择偏差。结果：基线样本包括6539名女性和2884名男性。女性的随访损失为17％，男性为2​​3％。平均值变化往往很小，但是随着时间的流逝，总体趋势是HRQOL降低。在老年人群和身体定向领域，变化更为明显。年龄较小的人群往往会取得较小的平均改善，尤其是在心理方面。较大的标准错误表明，从个体的角度而言，某些参与者的大幅度改善与其他参与者的大幅度下降是平衡的。结论：一般而言，加拿大人的HRQOL在5年内相对稳定。但是，在某些年龄或性别组中纵向评估HRQOL时应格外小心，因为与干预相关的变化可能会因HRQOL的自然进展而混淆。

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  • 来源
    《Quality of Life Research》 |2006年第3期|527-536|共10页
  • 作者

    Wilma M. Hopman; Claudie Berger; Lawrence Joseph; Tanveer Towheed; Elizabeth VandenKerkhof; Tassos Anastassiades; Jonathan D. Adachi; George Ioannidis; Jacques P. Brown; David A. Hanley; Emmanuel A. Papadimitropoulos;

  • 作者单位

    Clinical Research Centre Kingston General Hospital and Department of Community Health and Epidemiology Queen’s University Kingston Ontario K7L 2V7 Canada;

    CaMos Methods Centre McGill University Montreal Quebec Canada;

    Department of Epidemiology and Biostatistics McGill University Montreal Quebec Canada;

    Division of Rheumatology Department of Medicine Department of Community Health and Epidemiology Queen’s University Kingston Ontario Canada;

    Department of Anesthesiology School of Nursing Department of Community Health and Epidemiology Queen’s University Kingston Ontario Canada;

    Division of Rheumatology Department of Medicine Queen’s University Kingston Ontario Canada;

    Department of Medicine McMaster University Hamilton Ontario Canada;

    Department of Medicine McMaster University Hamilton Ontario Canada;

    Laval University Ste-Foy Quebec Canada;

    University of Calgary Calgary Alberta Canada;

    Faculty of Pharmacy Eli Lilly Canada Inc Toronto Canada and University of Toronto Toronto Canada;

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  • 正文语种 eng
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  • 关键词

    Longitudinal; Normative; Prospective; Quality of life; SF-36;

    机译：纵向;规范;预期;生活质量;SF-36;

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