...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiation and Environmental Biophysics >A two-mutation model of radiation-induced acute myeloid leukemia using historical mouse data
【24h】

A two-mutation model of radiation-induced acute myeloid leukemia using historical mouse data

机译：使用小鼠历史数据的辐射诱发的急性髓细胞白血病的两个突变模型

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

From studies of the atomic bomb survivors, it is well known that ionizing radiation causes several forms of leukemia. However, since the specific mechanism behind this process remains largely unknown, it is difficult to extrapolate carcinogenic effects at acute high-dose exposures to risk estimates for the chronic low-dose exposures that are important for radiation protection purposes. Recently, it has become clear that the induction of acute myeloid leukemia (AML) in CBA/H mice takes place through two key steps, both involving the Sfpi1 gene. A similar mechanism may play a role in human radiation-induced AML. In the present paper, a two-mutation carcinogenesis model is applied to model AML in several data sets of X-ray- and neutron-exposed CBA/H mice. The models obtained provide good fits to the data. A comparison between the predictions for neutron-induced and X-ray-induced AML yields an RBE for neutrons of approximately 3. The model used is considered to be a first step toward a model for human radiation-induced AML, which could be used to estimate risks of exposure to low doses.
机译：根据对原子弹幸存者的研究，众所周知，电离辐射会导致多种形式的白血病。但是，由于该过程背后的具体机制仍然未知，因此很难将急性高剂量暴露下的致癌作用外推至对于辐射防护目的很重要的慢性低剂量暴露的风险估计。最近，已经清楚的是，通过两个关键步骤在CBA / H小鼠中诱发急性髓细胞性白血病（AML），这两个关键步骤均涉及Sfpi1基因。类似的机制可能在人类辐射诱导的AML中起作用。在本文中，将两个突变的致癌模型应用于X射线和中子暴露的CBA / H小鼠的几个数据集中的AML模型。所获得的模型与数据非常吻合。对中子诱发的和X射线诱发的AML的预测之间的比较得出中子的RBE约为3。使用的模型被认为是迈向人类辐射诱发的AML模型的第一步，该模型可用于估计暴露于低剂量的风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号