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Real-time monitoring of the Bragg-peak position in ion therapy by means of single photon detection

机译：通过单光子检测实时监测离子治疗中的布拉格峰位置

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For real-time monitoring of the longitudinal position of the Bragg-peak during an ion therapy treatment, a novel non-invasive technique has been recently proposed that exploits the detection of prompt γ-rays issued from nuclear fragmentation. Two series of experiments have been performed at the GANIL and GSI facilities with 95 and 305 MeV/u 12C6+ ion beams stopped in PMMA and water phantoms. In both experiments, a clear correlation was obtained between the carbon ion range and the prompt photon profile. Additionally, an extensive study has been performed to investigate whether a prompt neutron component may be correlated with the carbon ion range. No such correlation was found. The present paper demonstrates that a collimated set-up can be used to detect single photons by means of time-of-flight measurements, at those high energies typical for ion therapy. Moreover, the applicability of the technique both at cyclotron and at synchrotron facilities is shown. It is concluded that the detected photon count rates provide sufficiently high statistics to allow real-time control of the longitudinal position of the Bragg-peak under clinical conditions.
机译：为了在离子疗法治疗期间实时监测布拉格峰的纵向位置，最近提出了一种新的非侵入性技术，该技术利用了对从核碎裂中发出的即时γ射线的检测。在GANIL和GSI设施上进行了两个系列的实验，分别在PMMA和水体模型中停止使用95和305 MeV / u 12 C 6 + 离子束。在这两个实验中，在碳离子范围和即时光子轮廓之间都获得了明确的相关性。另外，已经进行了广泛的研究以调查迅速中子成分是否可能与碳离子范围相关。找不到这样的相关性。本文证明了准直装置可用于通过飞行时间测量来检测单个光子，这些时间是离子治疗所典型的高能量。此外，还显示了该技术在回旋加速器和同步加速器设施中的适用性。结论是，检测到的光子计数率提供了足够高的统计量，以允许在临床条件下实时控制布拉格峰的纵向位置。

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