ENCAPSULATED 3,4,3-LI(1,2-HOPO) IN CHITOSAN NANOPARTICLES FOR DECORPORATION VIA INHALATION

Chen Sijing; Ko Raymond; Lai Edward P. C.; Wyatt Heather; Abergel Rebecca J.; Li Chunsheng

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ENCAPSULATED 3,4,3-LI(1,2-HOPO) IN CHITOSAN NANOPARTICLES FOR DECORPORATION VIA INHALATION

机译：壳聚糖纳米颗粒中包裹的3,4,3-LI（1,2-HOPO）可以通过吸入进行除菌

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3,4,3-LI(1,2-HOPO) has been identified as an excellent alternative for DTPA for decorporating actinides, such as Pu and Am, after internal contamination. Efforts have been focused on its application through oral administration. When 3,4,3-LI (1,2-HOPO) was encapsulated with biocompatible, biodegradable nanoparticles made of chitosan, its release from the nanoparticles to lung fluid, observed in in vitro experiments, exhibited an extended release profile. These observations were very encouraging, as this nanomedicine could lead to a reduction in the dosing frequency required to achieve the decorporation efficacy of unformulated 3,4,3-LI(1,2-HOPO) itself. In vivo release tests as well as actinide decorporation experiments, using an inhalation exposure animal model, will follow.

机译：3,4,3-LI（1,2-HOPO）已被证明是内部污染后脱除act系元素（例如Pu和Am）的DTPA的极佳替代品。努力集中在通过口服施用其上。当将3,4,3-LI（1,2-HOPO）用壳聚糖制成的生物相容性，可生物降解的纳米颗粒包封时，在体外实验中观察到的从纳米颗粒向肺液的释放显示出延长的释放特性。这些观察结果令人鼓舞，因为这种纳米药物可能导致实现未配制的3,4,3-LI（1,2-HOPO）本身的分解效力所需的给药频率降低。随后将进行使用吸入暴露动物模型的体内释放测试以及act系元素分解实验。

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来源
《Radiation Protection Dosimetry》 |2018年第1期|107-111|共5页
作者
Chen Sijing; Ko Raymond; Lai Edward P. C.; Wyatt Heather; Abergel Rebecca J.; Li Chunsheng;
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作者单位

Canadian Nucl Lab, Chalk River, ON, Canada;

Lawrence Berkeley Natl Lab, Chem Sci Div, Berkeley, CA USA;

Carleton Univ, Dept Chem, Ottawa, ON, Canada;

Hlth Canada, Radiat Protect Bur, Ottawa, ON, Canada;

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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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正文语种 eng
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1. Biomimetic actinide chelators: an update on the preclinical development of the orally active hydroxypyridonate decorporation agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO). [J] . Abergel RJ, Durbin PW, Kullgren B, Health Physics: Official Journal of the Health Physics Society . 2010,第3期

机译：仿生act系元素螯合剂：口服活性羟基吡啶酮解离剂3,4,3-LI（1,2-HOPO）和5-LIO（Me-3,2-HOPO）的临床前开发进展。
2. Solution thermodynamic evaluation of hydroxypyridinonate chelators 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO) for UO2(VI) and Th(IV) decorporation (Conference Paper) [J] . Sturzbecher-Hoehne M., Deblonde G.J.-P., Abergel R.J. Radiochimica Acta: International Journal for Chemical Aspects of Nuclear Science and Technology . 2013,第6期

机译：羟基吡啶鎓螯合剂3,4,3-LI（1,2-HOPO）和5-LIO（Me-3,2-HOPO）的溶液热力学评估，用于UO2（VI）和Th（IV）的脱附（会议论文）
3. Characterization, HPLC method development and impurity identification for 3,4,3-LI(1,2-HOPO), a potent actinide chelator for radionuclide decorporation [J] . Liu Mingtao, Wang Jennie, Wu Xiaogang, Journal of Pharmaceutical and Biomedical Analysis: An International Journal on All Drug-Related Topics in Pharmaceutical, Biomedical and Clinical Analysis . 2015,第Null期

机译：3,4,3-LI（1,2-HOPO）的表征，HPLC方法开发和杂质鉴定，这是一种用于放射性核素脱附的强act系螯合剂
4. Cytotoxicity evaluation of chitosan/alginate nanoparticles encapsulating antisense oligonudeotides and inhibition of EGFR expression in T47D cell line using RT-PCR [C] . Taraneh Gazori, Ismaeil Haririan, Shamileh Fouladdel, Annual meeting exposition of the Controlled Release Society . 2010

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5. Chitosan-Coated Cerium Oxide Nanoparticles and Sparfloxacin Encapsulated Polymersomes as a New Drug System with Antimicrobial Properties [D] . Zhao, Siqi. 2018

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机译：局部麻醉剂利多卡因封装的多辛 - 壳聚糖纳米粒子用于伤口愈合：
7. Biodistribution of the Multidentate Hydroxypyridinonate Ligand 14C-3,4,3-LI(1,2-HOPO), a Potent Actinide Decorporation Agent [O] . Taylor A. Choi, Aaron N. Endsley, Deborah I. Bunin, 2015

机译：多型羟基吡啶萘酸盐配体14c -3,4,3-li（1,2-hapo），一种有效的神光肌腱肌孢子（1,2-hobo）的生物分布
8. Biomimetic Actinide Chelators: An Update on the Preclinical Development of Orally Active Hydroxypyridonate Decorporation Agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO). [R] . Abergel, R. J., Durbin, P. W., Kullgen, B., 2011

机译：仿生肌动蛋白螯合剂：口服活性羟基吡啶类去氧剂3,4,3-LI（1,2-HOpO）和5-LIO（me-3,2-HOpO）的临床前开发的最新进展。

ENCAPSULATED 3,4,3-LI(1,2-HOPO) IN CHITOSAN NANOPARTICLES FOR DECORPORATION VIA INHALATION

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