首页> 外文期刊>Radiation Protection Dosimetry >A NOVEL METHOD TO ESTIMATE LYMPHOCYTE DOSE AND APPLICATION TO PEDIATRIC AND YOUNG ADULT CT PATIENTS IN THE UNITED KINGDOM
【24h】

A NOVEL METHOD TO ESTIMATE LYMPHOCYTE DOSE AND APPLICATION TO PEDIATRIC AND YOUNG ADULT CT PATIENTS IN THE UNITED KINGDOM

机译:估算淋巴细胞剂量的新方法及其在英国儿童和年轻成人CT患者中的应用

获取原文
获取原文并翻译 | 示例
           

摘要

Despite decades of epidemiological research, it remains uncertain whether ionizing radiation can cause lymphomas. Most epi-demiological studies of lymphoma risk following non-uniform exposure used dose to red bone marrow (RBM), constituting a small fraction of the lymphocytes, as a surrogate of dose to the lymphocytes. We developed a method to estimate dose to the lymphocytes using the reference distribution of lymphocytes throughout the body and Monte Carlo simulations of computational human phantoms. We applied our method to estimating lymphocyte doses for a pediatric CT patient cohort in the United Kingdom. Estimated dose to the RBM was greater than lymphocyte dose for most scan types (up to 2.6-fold higher, a 5-year-old brain scan) except abdomen scan (RBM dose was about half the lymphocyte dose, a 5-year-old abdomen scan). The lymphocyte dose in the UK cohort showed that T-spine and whole body scans delivered the highest lymphocyte doses (up to 22.4 mGy).
机译:尽管进行了数十年的流行病学研究,但仍不确定电离辐射是否会引起淋巴瘤。大部分非均匀暴露后的淋巴瘤风险流行病学研究都使用了红骨髓(RBM)剂量,该剂量占淋巴细胞的一小部分,代替了淋巴细胞剂量。我们开发了一种方法,该方法使用人体中淋巴细胞的参考分布和计算人体模型的蒙特卡罗模拟来估算淋巴细胞剂量。我们将我们的方法应用于估算英国儿童CT患者队列的淋巴细胞剂量。除了腹部扫描(RBM剂量约为淋巴细胞剂量的一半,即5岁)以外,对于大多数扫描类型,RBM的估计剂量均大于淋巴细胞剂量(最高可达2.6倍,5岁的大脑扫描)。腹部扫描)。英国队列中的淋巴细胞剂量显示T脊柱和全身扫描可提供最高的淋巴细胞剂量(高达22.4 mGy)。

著录项

  • 来源
    《Radiation Protection Dosimetry》 |2018年第1期|116-121|共6页
  • 作者单位

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA;

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA;

    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号