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首页> 外文期刊>Radiation Protection Dosimetry >NON-HUMAN PRIMATE TOTAL-BODY IRRADIATION MODEL WITH LIMITED AND FULL MEDICAL SUPPORTIVE CARE INCLUDING FILGRASTIM FOR BIODOSIMETRY AND INJURY ASSESSMENT
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NON-HUMAN PRIMATE TOTAL-BODY IRRADIATION MODEL WITH LIMITED AND FULL MEDICAL SUPPORTIVE CARE INCLUDING FILGRASTIM FOR BIODOSIMETRY AND INJURY ASSESSMENT

机译：具有有限剂量和完整药物支持的非人类主要全身照射模型，其中包括菲莫司特用于生物剂量测定和伤害评估

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摘要

An assessment of multiple biomarkers from radiation casualties undergoing limited- or full-supportive care including treatment with filgrastim is critical to develop rapid and effective diagnostic triage strategies. The efficacy of filgrastim with full-supportive care was compared with results with limited-supportive care by analyzing survival, necropsy, histopathology and serial blood samples for hematological, serum chemistry and protein profiles in a non-human primate (Macaco mulatto, male and female) model during 60-d post-monitoring period following sham- and total-body irradiation with 6.5 Gy ~(60)Co gamma-rays at 0.6 Gy min~(-1). Filgrastim (10μg kg~(-1) ) was administered beginning on Day 1 post-exposure and continued daily until neutrophil counts were ≥2,000 μL~(-1) for two consecutive days. Filgrastim and full-supportive care significantly decreased the pancytopenia duration and resulted in improved animal survival and recovery compared to animals with a limited-supportive care. These findings also identified and validated a multiparametric biomarker panel to support radiation diagnostic device development.
机译：对接受有限支持或全支​​持治疗（包括非格司亭治疗）的辐射伤员进行多种生物标志物评估，对于制定快速有效的诊断分类策略至关重要。通过分析非人类灵长类动物（Macaco mulatto，男性和女性）的存活，尸检，组织病理学和连续血样的血液学，血清化学和蛋白质谱，比较非格司亭在全支持治疗下的疗效与有限支持治疗的效果）模型在以6.5 Gy min〜（-1）的6.5 Gy〜（60）Co伽玛射线对假肢和全身照射后的60天监测后模型中。暴露后第1天开始给予非格司亭（10μgkg〜（-1）），并持续每天直至中性粒细胞计数≥2,000μL〜（-1）连续两天。与有限支持治疗的动物相比，非格司亭和全支持治疗显着减少了全血细胞减少症的持续时间，并改善了动物的存活和恢复。这些发现还确定并验证了支持放射诊断设备开发的多参数生物标志物组。

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  • 来源
    《Radiation Protection Dosimetry》 |2016年第3期|174-191|共18页
  • 作者

    Natalia I. Ossetrova; William F. Blakely; Vitaly Nagy; Camille McGann; Patrick H. Ney; Christine L. Christensen; Amory L. Koch; Jatinder Gulani; George B. Sigal; Eli N. Glezer; Kevin P. Hieber;

  • 作者单位

    Scientific Research Department, Armed Forces Radiobiology Research Institute (AFRRI),Uniformed Services University (USU), 8901 Wisconsin Avenue, Bethesda, ML 20889, USA;

    Scientific Research Department, Armed Forces Radiobiology Research Institute (AFRRI),Uniformed Services University (USU), 8901 Wisconsin Avenue, Bethesda, ML 20889, USA;

    Scientific Research Department, Armed Forces Radiobiology Research Institute (AFRRI),Uniformed Services University (USU), 8901 Wisconsin Avenue, Bethesda, ML 20889, USA;

    Scientific Research Department, Armed Forces Radiobiology Research Institute (AFRRI),Uniformed Services University (USU), 8901 Wisconsin Avenue, Bethesda, ML 20889, USA;

    Scientific Research Department, Armed Forces Radiobiology Research Institute (AFRRI),Uniformed Services University (USU), 8901 Wisconsin Avenue, Bethesda, ML 20889, USA;

    Scientific Research Department, Armed Forces Radiobiology Research Institute (AFRRI),Uniformed Services University (USU), 8901 Wisconsin Avenue, Bethesda, ML 20889, USA,Tri-Service Research Laboratory (TRSL), 4141 Petroleum Road, JBSA-Fort Sam Houston,TX 78234, USA;

    Scientific Research Department, Armed Forces Radiobiology Research Institute (AFRRI),Uniformed Services University (USU), 8901 Wisconsin Avenue, Bethesda, ML 20889, USA,Tripler Army Medical Center, Honolulu, HI 96859, USA;

    Scientific Research Department, Armed Forces Radiobiology Research Institute (AFRRI),Uniformed Services University (USU), 8901 Wisconsin Avenue, Bethesda, ML 20889, USA;

    Meso Scale Diagnostics, LLC. (MSD), 1601 Research Boulevard, Rockville, MD 20850, USA;

    Meso Scale Diagnostics, LLC. (MSD), 1601 Research Boulevard, Rockville, MD 20850, USA;

    Scientific Research Department, Armed Forces Radiobiology Research Institute (AFRRI),Uniformed Services University (USU), 8901 Wisconsin Avenue, Bethesda, ML 20889, USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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