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首页> 外文期刊>Radiation Protection Dosimetry >A FOLLOW-UP CYTOGENETIC STUDY OF WORKERS HIGHLY EXPOSED INSIDE THE CHERNOBYL SARCOPHAGUS
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A FOLLOW-UP CYTOGENETIC STUDY OF WORKERS HIGHLY EXPOSED INSIDE THE CHERNOBYL SARCOPHAGUS

机译：切尔诺贝格猴体内高度暴露的工人的后续细胞遗传学研究

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摘要

Data are presented on some of the engineers and scientists who regularly entered highly radioactive areas of the sarcophagus chamber constructed around the ruins of the Chernobyl reactor. Previous investigations on six of them by unstable chromosomal aberrations, quartz fibre electrometers and, in some cases, tooth electron spin resonance have all indicated high doses accumulated over several years of work inside the sarcophagus. Here, the authors present the data on eleven of the men who agreed to be monitored cytogenetically although two have since died aged 45 and 66 y. The present data were combined with the previous to examine the time-courses of these individuals' changes in their aberration frequencies. As expected, dicentric aberrations showed a clear drop down to 2-3 per 100 cells since the men ceased working inside the sarcophagus. In contrast, the translocation yields remained at a high level showing no tendency to decrease and so proved reliable for retrospective biodosimetry. These data are particularly useful in demonstrating the value of FISH long after high but protracted and fractionated exposure.
机译：数据提供了一些工程师和科学家的资料，这些工程师和科学家经常进入切尔诺贝利反应堆遗址周围建造的石棺室的高放射性区域。先前通过不稳定的染色体像差，石英纤维静电计以及在某些情况下牙齿电子自旋共振对其中六个进行的研究均表明，在石棺内部工作了数年后，积累了高剂量。在这里，作者介绍了同意接受细胞遗传学监测的11名男性的数据，尽管其中有2名已经死于45岁和66岁。本数据与以前的数据相结合，以检验这些人像差频率变化的时程。正如预期的那样，由于这些人停止在石棺内工作，双心像差明显下降至每100个细胞2-3个。相反，易位产量保持较高水平，没有降低的趋势，因此证明了其对回顾性生物剂量测定的可靠性。这些数据对于证明长时间但长期和分次暴露后的FISH值特别有用。

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  • 来源
    《Radiation Protection Dosimetry》 |2015年第4期|405-418|共14页
  • 作者

    I. K. Khvostunov; G. P. Snigiryova; V.V. Moiseenko; D. C. Lloyd;

  • 作者单位

    Medical Radiological Research Centre, Koroliova str. 4, Obninsk, Kaluga Region 249036, Russia;

    Ministry of Health of the Russian Federation, Federal State Budget Establishment Russian Scientific Center of Roentgenoradiology, Prophsoyuznaya str. 86, GSP-7, Moscow 117997, Russia;

    Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, CA 92093, USA;

    Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Chilton, Didcot, OX11 0RQ,UK;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
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