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EXPOSURE SET-UPS FOR IN VIVO EXPERIMENTS USING RADIAL WAVEGUIDES

机译:使用径向波的活体实验的曝光设置

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摘要

Radial waveguide set-ups are introduced as exposure devices for long-term experiments with large numbers of non-restrained animals exposed simultaneously. Methods are presented to ensure well-defined exposure conditions even for potentially overmoded waveguides and for the exposure of large groups of animals per cage. The proposed methods are applied for a four-generation study being performed on up to 2500 mice exposed to a generic UMTS test signal at prescribed averaged whole body specific absorption rates (SARs). The variation of the whole body SAR due to the movement of the mice inside the cage is calculated by using the finite-difference time-domain method and detailed animal models for selected configurations of the mice inside the cage for all stages of the study.
机译:径向波导装置作为曝光设备引入,用于长期实验,同时暴露了许多不受约束的动物。提出了一些方法来确保明确定义的暴露条件,即使是对于可能过大的波导以及每个笼子中大批动物的暴露。拟议的方法适用于四代研究,该研究针对多达2500只以规定的平均全身比吸收率(SAR)暴露于通用UMTS测试信号的小鼠进行。在研究的所有阶段,通过使用有限差分时域方法和详细的动物模型,针对笼内小鼠的选定配置,计算由于笼内小鼠运动引起的全身SAR变化。

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