• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiation Protection Dosimetry >DETERMINATION OF DOSE COEFFICIENTS AND URINARY EXCRETION FUNCTION FOR INHALATION OF CARBON-14-LABELLED BENZENE
【24h】

DETERMINATION OF DOSE COEFFICIENTS AND URINARY EXCRETION FUNCTION FOR INHALATION OF CARBON-14-LABELLED BENZENE

机译：吸入碳14标记的苯的剂量系数和尿排泄函数的测定

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Based on existing pharmacokinetic models for benzene, the distribution and retention of activity after inhalation of ~(14)C-labelled benzene in humans were studied. Six different benzene concentrations from 0.1 to 10,000 ppm (corresponding to activity concentrations between 9.6×10~(6) and 9.6×10~(11) Bq m~(-3)) and five exposure times from 0.1 to 1000 min were considered. The cumulated activities in the different organs and tissues and the urinary excretion rates were observed to depend non-linearly on the activity intake. The fraction of activity removed via urine varies between 52 and 10% of the intake. Nevertheless, for times that are long compared to the exposure duration the urinary excretion rate is determined by the activity clearance from adipose tissue and thus decreases at a constant rate. This decrease is common for all exposure conditions examined and thus allowed determining a mean urinary excretion rate and corresponding dose coefficients for committed equivalent doses as well as for the effective dose. The uncertainty of the dose coefficients is estimated to be about 50% for the exposure range covered. A 14-day interval for the incorporation monitoring by urine activity counting seems to be reasonable.
机译：根据现有的苯药代动力学模型，研究了〜（14）C标记的苯在人体中吸入后的活性分布和保留。考虑了六种不同的苯浓度，范围从0.1到10,000 ppm（对应于9.6×10〜（6）和9.6×10〜（11）Bq m〜（-3）的活性浓度）和五种暴露时间，从0.1到1000分钟。观察到不同器官和组织中的累积活动和尿排泄率与活动摄入量呈非线性关系。通过尿液去除的活动部分在摄入量的52％至10％之间变化。然而，对于与暴露时间相比较长的时间，尿排泄率取决于与脂肪组织的活动清除率，因此以恒定的速率降低。该降低对于所有检查的暴露条件都是常见的，因此可以确定平均尿排泄率和承诺等效剂量以及有效剂量的相应剂量系数。对于所覆盖的暴露范围，剂量系数的不确定性估计约为50％。通过尿液活动计数监测合并的时间间隔为14天似乎是合理的。

著录项

  • 来源
    《Radiation Protection Dosimetry》 |2003年第2期|p.139-152|共14页
  • 作者

  • 作者单位

    VKTA/Nuclear Engineering and Analytics Rossendorf Inc. Postfach 510119, D-01314 Dresden, Germany;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 TL72;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号