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首页> 外文期刊>Radiation Protection and Environment >A STUDY OF HELICOBACTER PYLORI INFECTION USING THE ~(14)C UBT METHOD
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A STUDY OF HELICOBACTER PYLORI INFECTION USING THE ~(14)C UBT METHOD

机译：〜（14）C UBT法研究幽门螺杆菌感染的研究

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摘要

Carbon-14 (~(14)C) is present in the environment and in all organic materials and behaves in the environment in the same manner as other carbon isotopes. In medicine, ~(14)C can be injected to study abnormalities of metabolism that underlie diabetes, gout, anaemia and acromegaly (adult "gigantism"), and for diagnosis of Helicobacter pylori (H. pylori). The discovery H. pylori by Warren and Marshall in 1982 changed the approach to treat peptic ulcer disease (PUD). Since then H. pylori has been the focus of clinical research and debate. The causal relationship between H. pylori infection and chronic gastritis is well established. H. pylori infection is one of the most common human infections worldwide. This organism has been shown to infect over half of the world's population. This article presents the application of ~(14)C Urea Breath Test (~(14)C UBT) for the diagnosis of the H. pylori bacteria which present in the stomach and duodenum. ~(14)C UBT relies on the urease activity of H. pylori to detect the presence of active infection. ~(14)C UBT has proved to be one of the most accurate methods for assessing H. pylori status. The ionizing radiation dose involved in this test is extremely low, much lower than the radiation dose due to natural sources. 209 samples collected from both symptomatic and non-symptomatic persons of Dakhina Kannada District, Karnataka were analysed and the results with discussion are presented in this paper.
机译：碳14（〜（14）C）存在于环境和所有有机材料中，并且在环境中的行为与其他碳同位素相同。在医学中，可以注入〜（14）C来研究糖尿病，痛风，贫血和肢端肥大症（成人“巨人症”）的代谢异常，并诊断幽门螺杆菌（H. pylori）。沃伦（Warren）和马歇尔（Marshall）于1982年发现幽门螺杆菌，改变了治疗消化性溃疡疾病（PUD）的方法。从那时起，幽门螺杆菌一直是临床研究和辩论的焦点。幽门螺杆菌感染与慢性胃炎之间的因果关系已得到充分证实。幽门螺杆菌感染是全世界最常见的人类感染之一。已经证明这种生物感染了世界一半以上的人口。本文介绍了〜（14）C尿素呼气试验（〜（14）C UBT）在胃和十二指肠中存在的幽门螺杆菌细菌诊断中的应用。 〜（14）C UBT依赖于幽门螺杆菌的脲酶活性来检测主动感染的存在。 〜（14）C UBT已被证明是评估幽门螺杆菌状态的最准确方法之一。该测试中涉及的电离辐射剂量极低，远低于自然来源的辐射剂量。分析了从卡纳塔克邦Dakhina Kannada区有症状和无症状人员收集的209个样本，并在讨论中给出了结果。

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  • 来源
    《Radiation Protection and Environment》 |2011年第3期|p.206-209|共4页
  • 作者

    Swaroop K.; Jayachandran; Shrikanth L. Patil; H. M. Somashekarappa;

  • 作者单位

    Centre for Application of Radioisotopes and Radiation Technology, Mangalore University, Mangalagangotri, Karnataka, India;

    Radioanalytical laboratory, Board of Radiation and Isotope Technology, Navi Mumbai, Maharashtra, Karnataka, India;

    Department of Physiology K S Hegde Medical Academy, NITTE University, Deralakatte, Mangalore, Karnataka, India;

    Centre for Application of Radioisotopes and Radiation Technology, Mangalore University, Mangalagangotri, Karnataka, India;

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  • 正文语种 eng
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  • 关键词

    ~(14)C urea breath test; helicobacter pylori; mucosa;

    机译：〜（14）C尿素呼气试验;幽门螺杆菌;黏膜;

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