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首页> 外文期刊>Recent Patents on Inflammation & Allergy Drug Discovery >Targeting Hypoxia-Inducible Factor-1 (HIF-1) Signaling in Therapeutics: Implications for the Treatment of Inflammatory Bowel Disease
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Targeting Hypoxia-Inducible Factor-1 (HIF-1) Signaling in Therapeutics: Implications for the Treatment of Inflammatory Bowel Disease

机译：靶向低氧诱导因子-1（HIF-1）信号治疗中：炎症性肠病的治疗意义。

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摘要

In response to hypoxia, adaptive hypoxia-inducible factor-1 (HIF-1) signaling events are activated to increase oxygen transport, anaerobic energy production and protective pathways to minimize ischemic tissue damage. Although the activation and subsequent induction of gene transcription by HIF-1 is normally associated with hypoxia, it is now established that HIF-1 signaling can be triggered under inflammatory conditions. HIF-1 has been implicated in a number of inflammatory diseases including rheumatoid arthritis, allergic asthma, psoriasis and inflammatory bowel disease (IBD). In the gastrointestinal tract, HIF-1-regulated gene products, such as vascular endothelial growth factor, intestinal trefoil factor and CD73, have been shown to provide protection in animal models of intestinal inflammation. Given the importance of HIF-1 signaling in the aforementioned diseases, there exists considerable interest in the development of methods to modulate HIF-1 expression as well as down-stream signaling events. This review examines HIF-1 signaling with a special focus on the gastrointestinal tract. The patents pertaining to the modulation of HIF-1 signaling are summarized, and their relevance to the treatment of inflammatory bowel disease is discussed.
机译：响应缺氧，激活适应性缺氧诱导因子1（HIF-1）信号转导事件，以增加氧气的转运，产生无氧能量和保护性途径，以最大程度地减少缺血性组织损伤。尽管HIF-1激活和随后的基因转录诱导通常与缺氧有关，但现在已经确定HIF-1信号传导可以在炎症条件下触发。 HIF-1与多种炎性疾病有关，包括类风湿性关节炎，过敏性哮喘，牛皮癣和炎性肠病（IBD）。在胃肠道中，已显示HIF-1调节的基因产物，例如血管内皮生长因子，肠三叶因子和CD73，可在动物肠道炎症模型中提供保护。考虑到HIF-1信号转导在上述疾病中的重要性，对调节HIF-1表达以及下游信号转导事件的方法的开发存在相当大的兴趣。这篇评论检查了HIF-1信号传导，特别关注胃肠道。总结了有关HIF-1信号调节的专利，并讨论了其与炎性肠病治疗的相关性。

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