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首页> 外文期刊>Redox Report >A comparative study by electron paramagnetic resonance of free radical species in the mainstream and sidestream smoke of cigarettes with conventional acetate filters and ‘bio-filters’
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A comparative study by electron paramagnetic resonance of free radical species in the mainstream and sidestream smoke of cigarettes with conventional acetate filters and ‘bio-filters’

机译：通过电子顺磁共振对卷烟主流烟气和侧流烟气中的自由基物质进行对比研究，并使用传统的醋酸纤维过滤嘴和“生物过滤嘴”

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摘要

Tobacco smoking is the most important extrinsic cause, after the diet, for increasing morbidity and mortality in humans. Unless current tobacco smoking patterns in industrialised and non-industrialised countries change, cigarettes will kill prematurely 10 million people a year by 2025. Greece is at the top of the list of European countries in cigarette consumption. In 1997, a Greek tobacco company introduced a new ‘bio-filter’ (BF) claiming that it reduces substantially the risks of smoking. In a recent publication [Deliconstantinos G, Villiotou V, Stavrides J. Scavenging effects of hemoglobin and related heme containing compounds on nitric oxide, reactive oxidants and carcinogenic volatile nitrosocompounds of cigarette smoke. A new method for protection against the dangerous cigarette constituents. Anticancer Res 1994; 14: 2717–2726] it was claimed that the new ‘bio-filter’ (activated carbon impregnated with dry hemoglobin) reduces certain toxic substances and oxidants (like NO, CO, NOx, H2O2, aldehydes, trace elements and nitroso-compounds) in the gas-phase of the mainstream smoke. We have investigated by electron paramagnetic resonance (EPR) the mainstream and sidestream smoke of the BF cigarette, in comparison with three other cigarettes with similar tar and nicotine contents, that have conventional acetate filters. We found that BF cigarette smoke has similar tar radical species with the same intensity EPR signals to those of the other cigarettes. The ability of the aqueous cigarette tar extracts to produce hydroxyl radicals (HO·), which were spin trapped by DMPO, was very similar to, or even higher than, the other 3 brands. The gas-phase of the mainstream smoke of the BF cigarette showed a 30–35% reduction in the production of oxygen-centered radicals (spin trapped with PBN). In the case of the sidestream smoke, BF cigarettes produced substantially higher concentrations of gas-phase radicals, compared to the other brands. These results suggest that BF is partially effective at removing some of the gas-phase oxidants but not effective in the reduction of tar and its radical species in the mainstream and sidestream smoke. It is well known from epidemiological studies that tar content is strongly associated with increasing risk to smokers of lung cancer. In our experiments, BF cigarettes produce a higher amount of tar and stable free radical species than the other 3 brands in the sidestream smoke (between puffs), thus potentially increasing risk to the smoker and passive smoker.
机译：在饮食中，吸烟是增加人类发病率和死亡率的最重要的外在原因。除非改变工业化国家和非工业化国家当前的吸烟方式，否则到2025年，卷烟将每年导致1000万人过早死亡。希腊是欧洲卷烟消费量最大的国家。 1997年，一家希腊烟草公司推出了一种新的“生物过滤嘴”（BF），声称它可以大大降低吸烟的风险。在最近的出版物中[Deliconstantinos G，Villiotou V，Stavrides J.血红蛋白和相关血红素化合物对香烟烟雾中一氧化氮，反应性氧化剂和致癌性挥发性亚硝基化合物的清除作用。一种防止危险卷烟成分的新方法。 1994年《抗癌研究》； 14：2717–2726]据称，新的“生物过滤器”（浸渍有干血红蛋白的活性炭）可减少某些有毒物质和氧化剂（如NO，CO，NOx，H 2 O <烟雾中气相中的sub> 2 ，醛，微量元素和亚硝基化合物）。我们已经通过电子顺磁共振（EPR）研究了高炉卷烟的主流烟气和侧流烟气，与其他三种具有类似焦油和尼古丁含量的，具有常规醋酸盐过滤嘴的烟气相比。我们发现高炉卷烟烟雾中的焦油自由基种类相似，而EPR信号的强度与其他卷烟相同。水性香烟焦油提取物产生被DMPO旋转捕获的羟基自由基（HO ·）的能力与其他三个品牌非常相似，甚至更高。高炉卷烟主流烟气的气相显示，以氧气为中心的自由基（被PBN捕获的自旋）的产生减少了30-35％。就侧流烟而言，与其他品牌相比，高炉卷烟产生的气相自由基浓度要高得多。这些结果表明，高炉在去除某些气相氧化剂方面部分有效，但在减少主流烟气和侧流烟气中的焦油及其自由基种类方面却无效。从流行病学研究众所周知，焦油含量与吸烟者罹患肺癌的风险增加密切相关。在我们的实验中，高炉香烟产生的焦油和稳定的自由基种类比其他3种品牌的侧流烟（抽吸之间）高，因此可能增加吸烟者和被动吸烟者的风险。

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  • 来源
    《Redox Report》 |2001年第3期|161-171|共11页
  • 作者

    Valavanidis A.; Haralambous E.;

  • 作者单位

    Department of Chemistry, University of Athens, University Campus Zografou, Athens, Greece;

    Department of Chemistry, University of Athens, University Campus Zografou, Athens, Greece;

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