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首页> 外文期刊>Redox Report >In vitro antioxidant and antiproliferative potential of medicinal plants used in traditional Indian medicine to treat cancer
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In vitro antioxidant and antiproliferative potential of medicinal plants used in traditional Indian medicine to treat cancer

机译：传统印度医学用于治疗癌症的药用植物的体外抗氧化剂和抗增殖潜力

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Objective: nnThe goal of this study was to evaluate the antioxidant and antiproliferative activities of 10 traditional medicinal plants, Asclepias curassavica, Ophiorrhiza mungos Linn., Cynodon dactylon (L.) Pers, Costus speciosus (J. Koenig.) Smith Costaceae, Achyranthes aspera L., Amaranthus tristis Roxb., Blepharis maderaspatensis L., Merremia emerginata Hall.f., Aegle marmelos Corr., and Tabernaemontana heyneana Wall., used in the traditional Indian system of medicine as a cure for cancer. The present study focuses on the anticancer potential of traditional medicinal plants to induce apoptosis in cancer cell lines. nnMethods: nnPlants were sequentially extracted with hexane, ethyl acetate, and methanol. The extract was concentrated to yield the crude extract, which was tested for antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl, nitric oxide and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assays on four cancer cell lines and a normal cell line. The anticancer potential of cytotoxic extracts was determined by the Annexin-fluorescein isothiocyanate-conjugated assay in human colon adenocarcinoma cell lines (COLO 320 DM). nnResults: nnAll the tested extracts showed significant antioxidant and antiproliferative activities in a concentration- and time-dependant manner in the following descending order: A. curassavica > C. dactylon > C. speciosus root > A. tristis > M. emarginata > O. mungos > T. Heyneana > B. maderaspatensis > A. marmelos > A. aspera. nnConclusion: nnThe results of the present study support the need of further studies to isolate potential anticancer drug with cancer cell-specific cytotoxicity. Additionally, the study supports the anticancer property of medicinal plants used in the traditional Indian medicine system and further evaluation of the selected medicinal plants for an effective anticancer drug with minimal side effects.
机译：目的：nn本研究的目的是评估10种传统药用植物的抗氧化和抗增殖活性，这些植物包括：Asclepias curassavica，Ophiorrhiza mungos Linn。，Cynodon dactylon（L.）Pers，Costus speciosus（J. Koenig。）Smith Costaceae，Achyranthes aspera L.，Amaranthus tristis Roxb。，Blepharis maderaspatensis L.，Merremia emerginata Hall.f.，Aegle marmelos Corr。和Tabernaemontana heyneana Wall。在印度传统医学体系中用于治疗癌症。本研究集中于传统药用植物在癌细胞系中诱导凋亡的抗癌潜力。 nn方法：nn依次用己烷，乙酸乙酯和甲醇萃取植物。浓缩提取物以得到粗提取物，将其使用1，1-二苯基-2-吡啶并肼，一氧化氮和3-（4，5-二甲基噻唑-2-基）-2，5-二苯基四唑测试其抗氧化活性。在四种癌细胞系和正常细胞系上进行溴化物检测。通过膜联蛋白-异硫氰酸荧光素共轭测定法在人结肠腺癌细胞系（COLO 320 DM）中确定了细胞毒性提取物的抗癌潜力。 nn结果：nn所有测试的提取物均以浓度和时间依赖性的方式按以下降序显示了显着的抗氧化和抗增殖活性：库拉索阿不体草>达氏梭菌>角皮草根>芒草> e。marginata>O。蒙哥斯> T.Heyneana> B.maderaspatensis> A. marmelos> A. aspera。 nn结论：nn本研究的结果支持需要进一步研究，以分离具有癌细胞特异性细胞毒性的潜在抗癌药物。此外，该研究支持在传统印度医学体系中使用的药用植物的抗癌特性，并支持对所选药用植物进一步评估其副作用最小的有效抗癌药物。

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