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Using systematic reviews for hazard and risk assessment of endocrine disrupting chemicals

机译：使用系统的审查来评估内分泌干扰物的危害和风险

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摘要

The possibility that endocrine disrupting chemicals (EDCs) in our environment contribute to hormonally related effects and diseases observed in human and wildlife populations has caused concern among decision makers and researchers alike. EDCs challenge principles traditionally applied in chemical risk assessment and the identification and assessment of these compounds has been a much debated topic during the last decade. State of the science reports and risk assessments of potential EDCs have been criticized for not using systematic and transparent approaches in the evaluation of evidence. In the fields of medicine and health care, systematic review methodologies have been developed and used to enable objectivity and transparency in the evaluation of scientific evidence for decision making. Lately, such approaches have also been promoted for use in the environmental health sciences and risk assessment of chemicals. Systematic review approaches could provide a tool for improving the evaluation of evidence for decision making regarding EDCs, e.g. by enabling systematic and transparent use of academic research data in this process. In this review we discuss the advantages and challenges of applying systematic review methodology in the identification and assessment of EDCs.
机译：我们环境中的内分泌干扰化学物质（EDC）可能导致人类和野生动植物种群中与荷尔蒙有关的效应和疾病，这引起了决策者和研究人员的关注。在过去的十年中，EDC挑战了传统上用于化学风险评估的原理，而这些化合物的识别和评估一直是争论不休的话题。批评了潜在EDC的科学报告和风险评估，因为它们没有在证据评估中使用系统和透明的方法。在医学和卫生保健领域，已经开发出系统的审查方法，并使用这些方法来使决策的科学证据评估具有客观性和透明度。最近，这种方法也被推广用于环境健康科学和化学物质的风险评估。系统审查方法可以提供一种工具，以改进对EDC决策的证据评估，例如：通过在此过程中系统，透明地使用学术研究数据。在这篇综述中，我们讨论了在鉴定和评估EDC时应用系统评价方法的优势和挑战。

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