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Thyroid nodules and thyroid autoimmunity in the context of environmental pollution

机译：环境污染背景下的甲状腺结节和甲状腺自身免疫

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摘要

Evidence suggests that in most industrialized countries autoimmune disorders, including chronic lymphocytic thyroiditis, are increasing. This increase parallels the one regarding differentiated thyroid cancer, the increment of which is mainly due to the papillary histotype. A number of studies have pointed to an association between chronic lymphocytic thyroiditis and differentiated thyroid cancer. The upward trend of these two thyroid diseases is sustained by certain environmental factors, such as polluting substances acting as endocrine disrupting chemicals. Herein we will review the experimental and clinical literature that highlights the effects of environmental and occupational exposure to polluting chemicals in the development of autoimmune thyroid disease or differentiated thyroid cancer. Stakeholders, starting from policymarkers, should become more sensitive to the consequences for the thyroid resulting from exposure to EDC. Indeed, the economic burden resulting from such consequences has not been quantified thus far.
机译：有证据表明，在大多数工业化国家，包括慢性淋巴细胞性甲状腺炎在内的自身免疫疾病正在增加。这种增加与关于分化型甲状腺癌的增加相似，其增加主要归因于乳头状组织型。大量研究指出，慢性淋巴细胞性甲状腺炎与分化型甲状腺癌之间存在关联。这两种甲状腺疾病的上升趋势是由某些环境因素所维持的，例如污染物质会破坏内分泌。在这里，我们将回顾实验和临床文献，这些文献着重介绍了环境和职业暴露于污染化学物质对自身免疫性甲状腺疾病或分化型甲状腺癌的发展的影响。从政策标记者开始，利益相关者应该对暴露于EDC对甲状腺的后果更加敏感。实际上，到目前为止，还没有量化由这种后果造成的经济负担。

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  • 来源
    《Reviews in Endocrine and Metabolic Disorders》 |2015年第4期|319-340|共22页
  • 作者

    Salvatore Benvenga; Alessandro Antonelli; Roberto Vita;

  • 作者单位

    Department of Clinical and Experimental Medicine University of Messina">(1);

    Master Program on Childhood Adolescent and Women’s Endocrine Health University of Messina School of Medicine">(2);

    Interdepartmental Program of Molecular and Clinical Endocrinology and Women’s Endocrine Health University Hospital Policlinico G. Martino">(3);

    Department of Clinical and Experimental Medicine University of Pisa">(4);

    Department of Clinical and Experimental Medicine University of Messina">(1);

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Pollution; Thyroid; Autoimmune thyroid diseases; Thyroid cancer;

    机译：污染;甲状腺;自身免疫性甲状腺疾病;甲状腺癌;

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