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首页> 外文期刊>Reviews in Endocrine and Metabolic Disorders >Environmental endocrine disruptors: Effects on the human male reproductive system
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Environmental endocrine disruptors: Effects on the human male reproductive system

机译：环境内分泌干扰物：对人类男性生殖系统的影响

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摘要

Incidences of altered development and neoplasia of male reproductive organs have increased during the last 50 years, as shown by epidemiological data. These data are associated with the increased presence of environmental chemicals, specifically “endocrine disruptors,” that interfere with normal hormonal action. Much research has gone into testing the effects of specific endocrine disrupting chemicals (EDCs) on the development of male reproductive organs and endocrine-related cancers in both in vitro and in vivo models. Efforts have been made to bridge the accruing laboratory findings with the epidemiological data to draw conclusions regarding the relationship between EDCs, altered development and carcinogenesis. The ability of EDCs to predispose target fetal and adult tissues to neoplastic transformation is best explained under the framework of the tissue organization field theory of carcinogenesis (TOFT), which posits that carcinogenesis is development gone awry. Here, we focus on the available evidence, from both empirical and epidemiological studies, regarding the effects of EDCs on male reproductive development and carcinogenesis of endocrine target tissues. We also critique current research methodology utilized in the investigation of EDCs effects and outline what could possibly be done to address these obstacles moving forward.
机译：流行病学数据显示，过去50年中，男性生殖器官发育和瘤形成改变的发生率有所增加。这些数据与干扰正常荷尔蒙作用的环境化学物质（特别是“内分泌干扰物”）的存在增加有关。在体外和体内模型中，许多研究已进入测试特定内分泌干扰化学物质（EDC）对男性生殖器官和内分泌相关癌症发展的影响。已做出努力，将应计的实验室发现与流行病学数据联系起来，以得出有关EDC，发育改变和致癌作用之间关系的结论。在致癌的组织组织场论（TOFT）的框架下，最好地解释了EDC易于使目标胎儿和成年组织发生肿瘤性转化的能力，该理论认为，致癌作用的发展出现了问题。在这里，我们着重从经验和流行病学研究中获得的有关EDC对雄性生殖发育和内分泌靶组织致癌作用的证据。我们还对当前在EDC效应研究中使用的研究方法进行了评论，并概述了可以解决这些障碍的方法。

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