• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Reviews in Endocrine and Metabolic Disorders >Polycystic ovary syndrome (PCOS) and endocrine disrupting chemicals (EDCs)
【24h】

Polycystic ovary syndrome (PCOS) and endocrine disrupting chemicals (EDCs)

机译：多囊卵巢综合征（PCOS）和内分泌干扰物（EDC）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Polycystic ovary syndrome (PCOS) is a heterogeneous disorder of unclear etiopathogenesis that is likely to involve genetic and environmental components synergistically contributing to its phenotypic expression. Endocrine disrupting chemicals (EDCs) and in particular Bisphenol A (BPA) represent a group of widespread pollutants intensively investigated as possible environmental contributors to PCOS pathogenesis. Substantial evidence from in vitro and animal studies incriminates endocrine disruptors in the induction of reproductive and metabolic aberrations resembling PCOS characteristics. In humans, elevated BPA concentrations are observed in adolescents and adult PCOS women compared to reproductively healthy ones and are positively correlated with hyperandrogenemia, implying a potential role of the chemical in PCOS pathophysiology, although a causal interference cannot yet be established. It is plausible that developmental exposure to specific EDCs could permanently alter neuroendocrine, reproductive and metabolic regulation favoring PCOS development in genetically predisposed individuals or it could accelerate and/or exacerbate the natural course of the syndrome throughout life cycle exposure.
机译：多囊卵巢综合征（PCOS）是一种病因不明的异质性疾病，可能涉及遗传和环境因素，共同促进其表型表达。破坏内分泌的化学物质（EDC），尤其是双酚A（BPA）代表了一组广泛的污染物，这些污染物被广泛研究作为PCOS发病机理的可能环境贡献者。体外和动物研究的大量证据表明，内分泌干扰物在诱导类似于PCOS特征的生殖和代谢异常中起重要作用。在人类中，与生殖健康者相比，青春期和成年PCOS妇女中BPA浓度升高，并且与高雄激素血症呈正相关，这暗示了该化学物质在PCOS病理生理中的潜在作用，尽管尚不能确定因果关系。有可能的是，暴露于特定EDCs可能会永久改变神经内分泌，生殖和代谢调节，从而有利于遗传易感人群中PCOS的发展，或者在整个生命周期暴露中可能加速和/或加重综合征的自然病程。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号