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A community participatory study of cardiovascular health and exposure to near-highway air pollution: study design and methods

机译：社区参与性心血管健康和近高速公路空气污染的研究：研究设计和方法

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摘要

Current literature is insufficient to make causal inferences or establish dose-response relationships for traffic-related ultrafine particles (UFPs) and cardiovascular (CV) health. The Community Assessment of Freeway Exposure and Health (CAFEH) is a cross-sectional study of the relationship between UFP and biomarkers of CV risk. CAFEH uses a community-based participatory research framework that partners university researchers with community groups and residents. Our central hypothesis is that chronic exposure to UFP is associated with changes in biomarkers. The study enrolled more than 700 residents from three near-highway neighborhoods in the Boston metropolitan area in Massachusetts, USA. All participants completed an in-home questionnaire and a subset (440+) completed an additional supplemental questionnaire and provided biomarkers. Air pollution monitoring was conducted by a mobile laboratory equipped with fast-response instruments, at fixed sites, and inside the homes of selected study participants. We seek to develop improved estimates of UFP exposure by combining spa-tiotemporal models of ambient UFP with data on participant time-activity and housing characteristics. Exposure estimates will then be compared with biomarker levels to ascertain associations. This article describes our study design and methods and presents preliminary findings from east Somerville, one of the three study communities.
机译：当前的文献不足以针对交通相关的超细颗粒（UFP）和心血管（CV）健康做出因果推断或建立剂量反应关系。高速公路暴露与健康社区评估（CAFEH）是UFP与CV风险生物标志物之间关系的横断面研究。 CAFEH使用基于社区的参与性研究框架，该框架将大学研究人员与社区团体和居民合作。我们的中心假设是，长期暴露于UFP与生物标志物的变化有关。该研究招募了来自美国马萨诸塞州波士顿都会区三个近高速公路社区的700多名居民。所有参与者填写了一份家庭问卷，一部分（440+）完成了一份补充问卷并提供了生物标记。空气污染监测是由配备了快速反应仪器的流动实验室在固定地点和选定研究参与者的房屋内进行的。我们试图通过结合周围UFP的时空模型与参与者时间活动和住房特征的数据来开发出对UFP暴露的改进估计。然后将暴露估计值与生物标志物水平进行比较，以确定相关性。本文介绍了我们的研究设计和方法，并提出了来自三个研究社区之一的东萨默维尔的初步发现。

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  • 来源
    《Reviews on environmental health》 |2013年第1期|21-35|共15页
  • 作者

    Christina H. Fuller; Allison P. Patton; Kevin Lane; M. Barton Laws; Aaron Marden; Edna Carrasco; John Spengler; Mkaya Mwamburi; Wig Zamore; John L. Durant; Doug Brugge;

  • 作者单位

    Institute of Public Health, Georgia State University, P.O. Box 3995, Atlanta, GA 30302-3995, USA Department of Environmental Health,Harvard School of Public Health, Boston. MA, USA;

    Department of Civil and Environmental Engineering, Tufts University School of Engineering,Medford, MA, USA;

    Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA;

    Health Services Policy and Practice, Brown University, Providence, RI, USA;

    Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston,MA, USA;

    Committee for Boston Public Housing, Boston, MA, USA;

    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA;

    Department of Public Health and Family Medicine, Tufts University School of Medicine, Boston,MA, USA;

    Somerville Transportation Equity Partnership,Somerville, MA, USA;

    Department of Civil and Environmental Engineering, Tufts University School of Engineering,Medford, MA, USA;

    Department of Public Health and Family Medicine, Tufts University School of Medicine, 136 Harrison Avenue,Boston, MA 02111, USA;

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  • 正文语种 eng
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  • 关键词

    biomarker; Community Assessment of Freeway Exposure and Health (CAFEH); community-based participatory research (CBPR); ultrafine particles;

    机译：生物标志物高速公路暴露与健康社区评估（CAFEH）;基于社区的参与性研究（CBPR）;超细颗粒;

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