• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Reviews on environmental health >Exposure to leachate from municipal battery recycling site: implication as key inhibitor of steroidogenic enzymes and risk factor of prostate damage in rats
【24h】

Exposure to leachate from municipal battery recycling site: implication as key inhibitor of steroidogenic enzymes and risk factor of prostate damage in rats

机译：从市政电池回收场暴露于渗滤液：可能是类固醇生成酶的主要抑制剂和大鼠前列腺损害的危险因素

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Few or no studies have measured the effect of short- and long-term exposure to industrial leachate. Mature male Wistar strain albino rats (175-220 g) underwent sub-chronic exposure to leachate from the Elewi Odo municipal battery recycling site (EOMABRL) via oral administration for a period of 60 days at different doses (20%, 40%, 60%, 80%, and 100%) per kilogram of body weight to evaluate the toxic effects of the leachate on male reproductive function using steroidogenic enzymes and biomarkers of prostate damage. Control groups were treated equally but were given distilled water instead of the leachate. After the treatment periods, results showed that the treatment induced systemic toxicity at the doses tested by causing a significant (p＜0.05) loss in absolute body weight and decline in growth rate. There was a marked significant decrease (p＜0.05) in testicular activities of A~5-3β-hydroxysteroid dehydrogenase and 17β-hydroxysteroid dehydrogenase. Conversely, the activity of prostatic acid phosphatase, a key marker enzyme for prostrate damage was significantly (p＜0.05) elevated in the treated rats. Similarly, the administration of EOMABRL significantly (p＜0.05) exacerbated the activity of total acid phosphatase with concomitant increase in the activity of prostatic alkaline phosphatase. These findings conclude that exposure to leachate from a battery recycling site induces sub-chronic testicular toxicity by inhibiting key steroidogenic enzymes and activating key markers linked with prostate damage/cancer in rats.
机译：很少或没有研究测量短期和长期接触工业渗滤液的影响。成熟的雄性Wistar变种白化病大鼠（175-220 g）通过口服以不同剂量（20％，40％，60、60％）亚慢性暴露于Elewi Odo市政电池回收站（EOMABRL）的沥出液中百分比，80％和100％），以使用类固醇生成酶和前列腺损伤的生物标记物评估渗滤液对男性生殖功能的毒性作用。对照组得到同等对待，但给予蒸馏水代替渗滤液。在治疗期之后，结果表明，该治疗以所测试的剂量引起全身毒性，导致绝对体重显着（p ＜0.05）下降和生长速率下降。 A〜5-3β-羟类固醇脱氢酶和17β-羟类固醇脱氢酶的睾丸活性显着下降（p ＜0.05）。相反，在前列腺癌中，前列腺酸性磷酸酶的活性显着升高（p ＜0.05），而前列腺酸性磷酸酶是前列腺损伤的关键标志酶。同样，施用EOMABRL显着（p ＜0.05）加剧了总酸性磷酸酶的活性，同时增加了前列腺碱性磷酸酶的活性。这些发现得出结论，从电池回收站接触浸出液可通过抑制大鼠中关键的类固醇生成酶和激活与前列腺损害/癌症相关的关键标志物而诱发亚慢性睾丸毒性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号