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首页> 外文期刊>Reviews on environmental health >The fate and behavior of persistent,bioaccumulative, and toxic (PBT) chemicals:examining lead (Pb) as a PBT metal
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The fate and behavior of persistent,bioaccumulative, and toxic (PBT) chemicals:examining lead (Pb) as a PBT metal

机译：持久性，生物蓄积性和有毒（PBT）化学品的命运和行为：检查铅（Pb）作为PBT金属

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Persistent, bioaccumulative, and toxic (PBT) chemicals are a class of chemicals that resist degradation and persist in the environment for extensive periods. As a result of their persistence, when these chemicals are consumed, they bioaccumulate in the fat tissues, bones, and brain of organisms. Lead (Pb) is a PBT metal with the ability to bind irreversibly to neurons and to mimic natural minerals like calcium and zinc. The aim of this review is to examine the unique properties of a PBT, like Pb, as well as the analytic methods of detecting and characterizing PBTs. This review offers sections that explore Pb's persistence in the environment, bioaccumulation in fish and birds, and toxic characteristics in the human body. It further examines how Pb's effects on transcription factors could explain the observed Pb lines in Pb-poisoned individuals. This review also evaluates the relationship between the properties of persistence and bioaccumulation as a means to determine whether or not they are interconnected, interdependent, or independent of one another.
机译：持久性，生物蓄积性和有毒（PBT）化学品是一类能够抵抗降解并在环境中长期存在的化学品。由于它们的持久性，食用这些化学物质时，它们会在生物的脂肪组织，骨骼和大脑中生物蓄积。铅（Pb）是一种PBT金属，具有不可逆地与神经元结合并模仿钙和锌等天然矿物质的能力。这篇综述的目的是检查PBT（如Pb）的独特特性，以及检测和表征PBT的分析方法。这篇评论提供了一些章节，探讨了铅在环境中的持久性，鱼类和鸟类的生物蓄积性以及对人体的毒性特征。它进一步研究了铅对转录因子的影响如何解释在铅中毒的个体中观察到的铅系。这篇综述还评估了持久性和生物蓄积性之间的关系，以此来确定它们是否相互关联，相互依存或彼此独立。

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