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首页> 外文期刊>Rheumatology >Sjögren's updateIP55. Pregnancy In Sjögren’s Syndrome And Neonatal LupusIP56. How Will T-Cell Basic Science Research Driven Treatment in Sjögren's Syndrome?IP57. How Will B-Cell Basic Science Research Drive Treatment In Sjögren’s Syndrome?
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Sjögren's updateIP55. Pregnancy In Sjögren’s Syndrome And Neonatal LupusIP56. How Will T-Cell Basic Science Research Driven Treatment in Sjögren's Syndrome?IP57. How Will B-Cell Basic Science Research Drive Treatment In Sjögren’s Syndrome?

机译：Sjögren的updateIP55。舍格伦综合征和新生儿狼疮的孕妇IP56。 T细胞基础科学研究如何在干燥综合征中推动治疗？IP57。 B细胞基础科学研究如何推动干燥综合征的治疗？

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摘要

Primary Sjögren's syndrome is an autoimmune connective tissue disease characterised by dry eyes and mouth with foci of infiltrating lymphocytes on salivary gland biopsy. It is relatively under-diagnosed and often under treated. The clinical presentation may be non-specific and it is not uncommon for symptoms to have been present for up to 10 years before the diagnosis is made. Approximately 60% of patients carry the characteristic anti Ro and/or La antibodies and tend to have a more systemic form of the disease and present younger. Extra-glandular features are common and often include fatigue and arthralgia. There is an association with other autoimmune diseases including autoimmune thyroid disease and primary biliary cirrhosis. Patients often present late, in part because they adapt to the symptoms but also because there is significant salivary and tear reserve which means that salivary flow rates may have fallen to 30-40% of normal before a patient complains of a dry mouth. Traditionally treatment has been symptomatic with topical salivary and tear substitutes. There is evidence however that active treatment, especially in the early stages of the disease, may be beneficial. Treatment with hydroxychloroquine is supported by anecdotal evidence and studies confirm an improvement in fatigue and a lowering of immunoglobulin levels.
机译：原发性干燥综合征是一种自身免疫性结缔组织病，其特征是唾液腺活检时眼干口干，浸润淋巴细胞灶。相对来说，它的诊断不足，而且常常得不到治疗。临床表现可能是非特异性的，并且在做出诊断之前长达10年的症状并不罕见。大约60％的患者携带特征性的抗Ro和/或La抗体，并且倾向于更全身性地发病，并且年龄较小。腺外特征很常见，通常包括疲劳和关节痛。与其他自身免疫性疾病相关，包括自身免疫性甲状腺疾病和原发性胆汁性肝硬化。患者通常会迟到，部分原因是因为他们适应了症状，还因为唾液和泪液储备丰富，这意味着在患者抱怨口干之前，唾液流速可能已降至正常水平的30-40％。传统上，局部唾液和泪液替代疗法是对症治疗。但是，有证据表明，积极治疗，特别是在疾病的早期阶段，可能是有益的。传闻证据支持使用羟氯喹进行治疗，研究证实疲劳性得到改善，免疫球蛋白水平降低。

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    《Rheumatology》 |2011年第3期|p.12-13|共2页
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    Elizabeth Price;

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