The expression of SOCS is altered in rheumatoid arthritis

P. Isom?ki; T. Alan?r?; P. Isohanni; A. Lagerstedt; M. Korpela; T. Moilanen; T. Visakorpi; and O. Silvennoinen

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The expression of SOCS is altered in rheumatoid arthritis

机译：类风湿关节炎中SOCS的表达发生改变

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Objectives. Cytokines play a key pathogenic role in rheumatoid arthritis (RA). Several cytokines signal through the JAK-STAT pathway, which is negatively regulated by the suppressors of cytokine signalling (SOCS) proteins. Since SOCS protein levels can profoundly modulate cellular responses to cytokines, we have investigated their expression in chronic RA.

机译：目标。细胞因子在类风湿关节炎（RA）中起着关键的致病作用。几种细胞因子通过JAK-STAT途径进行信号传导，该途径受细胞因子信号传导（SOCS）蛋白抑制因子的负调控。由于SOCS蛋白水平可以深刻调节细胞对细胞因子的反应，因此我们研究了它们在慢性RA中的表达。

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《Rheumatology》 |2007年第10期|1538-1546|共9页
作者
P. Isom?ki; T. Alan?r?; P. Isohanni; A. Lagerstedt; M. Korpela; T. Moilanen; T. Visakorpi; and O. Silvennoinen;
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作者单位

Institute of Medical Technology University of Tampere;

Department of Internal Medicine Division of Rheumatology;

Department of Pathology;

Laboratory Centre;

Department of Clinical Microbiology Tampere University Hospital and;

Coxa Hospital for Joint Replacement Tampere Finland.;

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1. The expression of SOCS is altered in rheumatoid arthritis. [J] . Isomaki P, Alanara T, Isohanni P, Rheumatology . 2007,第10期

机译：类风湿关节炎中SOCS的表达发生改变。
2. LncRNA LINC-PINT increases SOCS1 expression by sponging miR-155-5p to inhibit the activation of ERK signaling pathway in rheumatoid arthritis synovial fibroblasts induced by TNF-alpha [J] . International immunopharmacology . 2020,第期

机译：LNCRNA LINC-PINT通过冲水-155-5p增加SOCS1表达，以抑制TNF-α诱导的类风湿性关节炎滑膜纤维细胞中ERK信号通路的激活
3. Effects of miR-150-5p on the growth and SOCS1 expression of rheumatoid arthritis synovial fibroblasts [J] . Qiu Miangliang, Mo Lisha, Li Juxiang, Clinical rheumatology . 2020,第3期

机译：miR-150-5p对类风湿性关节炎滑膜成纤维细胞生长和SOCS1表达的影响
4. Identification of candidate genes for Rituximab response in rheumatoid arthritis with weighted gene co-expression network analysis [C] . Guiying Dong, Zhi-Ping Liu, Rui Gao, Chinese Automation Congress . 2017

机译：用加权基因共表达网络分析鉴定类风湿关节炎中利妥昔单抗反应的候选基因
5. Rheumatoid arthritis and osteoarthritis synovial fibroblasts express FcalphaR (CD89) in vitro and in vivo: Implications for rheumatoid arthritis. [D] . Wover, Roberta Michelle Antoinette. 2006

机译：类风湿关节炎和骨关节炎滑膜成纤维细胞在体外和体内表达FcalphaR（CD89）：对类风湿关节炎的影响。
6. Role of lentivirus-mediated overexpression of SOCS3 in proliferation and apoptosis of fibroblasts-like synoviocytes in Lewis rats with adjuvant-induced rheumatoid arthritis [O] . Jia-Jing Zhu, Zong-Qiang Wang, Li-Qi Bi, 2018

机译：慢病毒介导的SOCS3过表达在佐剂性类风湿关节炎Lewis大鼠中的成纤维样滑膜细胞增殖和凋亡中的作用
7. The expression of SOCS is altered in rheumatoid arthritis [O] . P. Isohanni, A. Lagerstedt, M. Korpela, 2015

机译：sOCs的表达在类风湿性关节炎中发生改变

The expression of SOCS is altered in rheumatoid arthritis

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