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首页> 外文期刊>Rheumatology >Radiosynoviorthesis of medium-sized joints with rhenium-186-sulphide colloid: a review of the literature
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Radiosynoviorthesis of medium-sized joints with rhenium-186-sulphide colloid: a review of the literature

机译：186186-硫化胶体对中型关节的放射性滑脱术：文献综述

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摘要

Hypertrophy and inflammation of the synovium with various underlying pathologies—such as rheumatoid arthritis, osteoarthritis, haemophilia and spondyloarthropathy—can be treated successfully by radiosynoviorthesis (RSO). For medium-sized joints (shoulder, elbow, wrist, hip and ankle), the radionuclide of choice is rhenium-186. We review the evidence for the efficacy of this local, relatively non-invasive therapy and evaluate its benefits and risks. We conclude good evidence of rhenium-186 RSO in rheumatoid arthritis and haemophilic arthropathy. In the remaining pathologies, up to now, the therapeutic efficacy has not been confirmed by today's most stringent criteria for clinical studies. The available data support rhenium-186 RSO as a suitable second-line treatment for patients in whom other therapies (including locally injected corticoids) have failed, as long as proper attention is paid to correct administration—including post-treatment immobilization and the co-administration of corticoids.
机译：滑膜增生和炎症具有多种潜在的病理学特征，例如类风湿性关节炎，骨关节炎，血友病和脊椎关节炎，可以通过放射性滑膜置换术（RSO）成功治疗。对于中等大小的关节（肩部，肘部，腕部，臀部和脚踝），选择的放射性核素是-186。我们回顾了这种局部非侵入性疗法的有效性的证据，并评估了其益处和风险。我们总结了类风湿性关节炎和血友病性关节炎中rh186 RSO的良好证据。在迄今为止的其余病理中，尚未通过当今临床研究中最严格的标准来确认治疗效果。现有数据支持en186 RSO作为其他疗法（包括局部注射的皮质类固醇）治疗失败的患者的合适的二线治疗，只要适当注意正确的给药方法（包括治疗后固定和联合治疗）即可。皮质激素的管理。

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  • 来源
    《Rheumatology》 |2007年第10期|1531-1537|共7页
  • 作者

    R. Klett U. Lange; H. Haas; M. Voth; and J. Pinkert;

  • 作者单位

    Department of Nuclear Medicine University Hospital Giessen and Marburg GmbH Giessen Germany;

    Kerckhoff-Hospital Department of Rheumatology Bad Nauheim;

    Hospital association Bonn Department of Orthopedics and Surgery Bonn;

    Bayer Schering Pharma Berlin and;

    Schering Deutschland GmbH Berlin Germany.;

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