• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Risk analysis >Linear-No-Threshold Default Assumptions are Unwarranted for Cytotoxic Endpoints Independently Triggered by Ultrasensitive Molecular Switches
【24h】

Linear-No-Threshold Default Assumptions are Unwarranted for Cytotoxic Endpoints Independently Triggered by Ultrasensitive Molecular Switches

机译：对于由超灵敏分子开关独立触发的细胞毒性终点，不需要线性无阈值默认假设

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Crump's response in this issue to my critique of linear-no-threshold (LNT) default assumptions for noncancer and nongenotoxic cancer risks (Risk Analysis 2016; 36(3):589-604) is rebutted herein. Crump maintains that distinguishing between a low-dose linear dose response and a threshold dose response on the basis of dose-response data is impossible even for endpoints involving increased cytotoxicity. My rebuttal relies on descriptions and specific illustrations of two well-characterized ultrasensitive molecular switches that govern two key cytoprotective responses to cellular stressheat shock response and antioxidant response element activation, respectivelyeach of which serve to suppress stress-induced apoptotic cell death unless overwhelmed. Because detailed dose-response data for each endpoint is shown to be J- or inverted-J-shaped with high confidence, and because independent pathways can explain background rates of apoptosis, LNT assumptions for this cytotoxic endpoint are unwarranted, at least in some cases and perhaps generally.
机译：本文驳斥了Crump在此问题上对我对非癌和非遗传毒性癌症风险的线性无阈值（LNT）默认假设的批评的回应（Risk Analysis 2016; 36（3）：589-604）。 Crump坚持认为，即使对于涉及细胞毒性增加的终点，也无法基于剂量反应数据区分低剂量线性剂量反应和阈值剂量反应。我的反驳依赖于两个特征充分的超灵敏分子开关的描述和具体说明，它们分别控制对细胞应激的两个关键的细胞保护反应，热休克反应和抗氧化剂反应元件的激活，它们每个都可以抑制应激诱导的凋亡细胞死亡，除非不知所措。由于每个终点的详细剂量反应数据均显示为J形或倒J形，并且具有很高的置信度，并且由于独立的通路可以解释细胞凋亡的背景发生率，因此至少在某些情况下，对于这种细胞毒性终点的LNT假设没有根据也许一般而言。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号