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Expert Views on Biological Threat Characterization for the U.S. Government: A Delphi Study

机译：美国政府对生物威胁特征的专家观点：Delphi研究

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摘要

Biological threat characterization (BTC) involves laboratory research conducted for the purpose of biological defense. BTC research is important for improving biological risk assessment and informing resource prioritization. However, there are also risks involved in BTC work, including potential for escape from the laboratory or the misuse of research results. Using a modified Delphi study to gather opinions from U.S. experts in biosecurity and biodefense, this analysis explores what principles and safeguards can maximize the benefits of BTC research and ensure that it is conducted safely and securely. Delphi participants were asked to give their opinions about the need for BTC research by the U.S. government (USG); risks of conducting this research; rules or guidelines that should be in place to ensure that the work is safe and accurate; components of an effective review and prioritization process; rules for when characterization of a pathogen can be discontinued; and recommendations about who in the USG should be responsible for BTC prioritization decisions. The findings from this research reinforce the need for BTC research at the federal level as well as a need for continued review and oversight of this research to maximize its effectiveness and reduce the risks involved. It also demonstrates the need for further discussion of what would constitute a red line for biothreat characterization researchresearch that should not be performed for safety, ethical, or practical reasonsand guidelines for when there is sufficient research in a given topic area so that the research can be considered completed.
机译：生物威胁特征（BTC）涉及为进行生物防御而进行的实验室研究。 BTC研究对于改善生物风险评估和告知资源优先次序很重要。但是，BTC工作也存在风险，包括可能逃离实验室或滥用研究结果。使用经过修改的Delphi研究收集美国生物安全和生物防御专家的意见，该分析探索了哪些原则和保障措施可以最大程度地发挥BTC研究的益处并确保安全可靠地进行。美国政府（USG）要求Delphi参与者就BTC研究的必要性发表意见。进行这项研究的风险；为确保工作安全准确而应制定的规则或准则；有效审查和优先排序过程的组成部分；何时可以中断病原体表征的规则；以及有关USG中谁应负责BTC优先级决策的建议。这项研究的发现加强了联邦一级对BTC研究的需求，并且需要对该研究进行持续的审查和监督，以最大程度地发挥其效力并降低涉及的风险。它还表明有必要进一步讨论什么构成生物威胁特征研究的红线，出于安全，道德或实际原因，以及在给定主题领域进行充分研究时，不应进行指南，以便可以进行研究。认为已完成。

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