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首页> 外文期刊>Risk analysis >Risk Reduction Modeling of High Pathogenicity Avian Influenza Virus Titers in Nonpasteurized Liquid Egg Obtained from Infected but Undetected Chicken Flocks
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Risk Reduction Modeling of High Pathogenicity Avian Influenza Virus Titers in Nonpasteurized Liquid Egg Obtained from Infected but Undetected Chicken Flocks

机译：从感染但未发现的鸡群获得的未经巴氏消毒的液态蛋中高致病性禽流感病毒滴度的风险降低模型

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摘要

Control of highly pathogenic avian influenza (HPAI) outbreaks in poultry has traditionally involved the establishment of disease containment zones, where poultry products are only permitted to move from within a zone under permit. Nonpasteurized liquid egg (NPLE) is one such commodity for which movements may be permitted, considering inactivation of HPAI virus via pasteurization. Active surveillance testing at the flock level, using targeted matrix gene real-time reversed transcriptase-polymerase chain reaction testing (RRT-PCR) has been incorporated into HPAI emergency response plans as the primary on-farm diagnostic test procedure to detect HPAI in poultry and is considered to be a key risk mitigation measure. To inform decisions regarding the potential movement of NPLE to a pasteurization facility, average HPAI virus concentrations in NPLE produced from a HPAI virus infected, but undetected, commercial table-egg-layer flock were estimated for three HPAI virus strains using quantitative simulation models. Pasteurization under newly proposed international design standards (5 log10 reduction) is predicted to inactivate HPAI virus in NPLE to a very low concentration of less than 1 embryo infectious dose (EID) 50/mL, considering the predicted virus titers in NPLE from a table-egg flock under active surveillance. Dilution of HPAI virus from contaminated eggs in eggs from the same flock, and in a 40,000 lb tanker-truck load of NPLE containing eggs from disease-free flocks was also considered. Risk assessment can be useful in the evaluation of commodity-specific risk mitigation measures to facilitate safe trade in animal products from countries experiencing outbreaks of highly transmissible animal diseases.
机译：控制家禽中的高致病性禽流感（HPAI）爆发通常涉及建立疾病遏制区，在该区中，仅允许家禽产品在获得许可的区域内移动。考虑到通过巴氏灭菌使HPAI病毒失活，非巴氏灭菌的液态蛋（NPLE）是一种可以允许移动的商品。使用目标基质基因实时逆转录聚合酶链反应测试（RRT-PCR）在鸡群上进行主动监视测试已作为HPA应急诊断计划中的主要农场诊断测试程序纳入了HPAI应急计划中被认为是减轻风险的关键措施。为了指导有关NPLE可能转移到巴氏灭菌设备的决策，使用定量模拟模型估算了三种HPAI病毒株感染的HPAI病毒但未检测到的商用表蛋层羊群产生的NPLE中平均HPAI病毒浓度。考虑到表中NPLE中预测的病毒滴度，根据新提议的国际设计标准进行的巴氏杀菌（降低5 log10）可将NPLE中的HPAI病毒灭活至非常低的浓度，低于1个胚胎感染剂量（EID）50 / mL。积极监视下的蛋群。还考虑了从同一鸡群的鸡蛋中污染的鸡蛋中稀释HPAI病毒，以及在无病鸡群的40,000磅油轮卡车装载NPLE的鸡蛋中进行稀释。风险评估可用于评估针对特定商品的风险缓解措施，以促进来自高传染性动物疾病暴发国家的动物产品安全贸易。

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