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Dose-Response Model of Rocky Mountain Spotted Fever (RMSF) for Human

机译：落基山斑疹热（RMSF）对人的剂量反应模型

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摘要

Rickettsia rickettsii is the causative agent of Rocky Mountain spotted fever (RMSF) and is the prototype bacterium in the spotted fever group of rickettsiae, which is found in North, Central, and South America. The bacterium is gram negative and an obligate intracellular pathogen. The disease is transmitted to humans and vertebrate host through tick bites; however, some cases of aerosol transmission also have been reported. The disease can be difficult to diagnose in the early stages, and without prompt and appropriate treatment, it can be fatal. This article develops dose-response models of different routes of exposure for RMSF in primates and humans. The beta-Poisson model provided the best fit to the dose-response data of aerosol-exposed rhesus monkeys, and intradermally inoculated humans (morbidity as end point of response). The average 50% infectious dose among (ID50) exposed human population, N50, is 23 organisms with 95% confidence limits of 1 to 89 organisms. Similarly, ID10 and ID20 are 2.2 and 5.0, respectively. Moreover, the data of aerosol-exposed rhesus monkeys and intradermally inoculated humans could be pooled. This indicates that the dose-response models fitted to different data sets are not significantly different and can be described by the same relationship.
机译：立克次体立克次氏体是落基山斑点热（RMSF）的病原体，并且是立克次体斑点热群中的原型细菌，该群在北美洲，中美洲和南美洲都有发现。该细菌是革兰氏阴性菌和专性细胞内病原体。该病通过tick叮咬传播给人类和脊椎动物。但是，也有一些气雾传播的案例。该病可能难以在早期诊断，并且如果不及时采取适当的治疗措施，可能会致命。本文开发了灵长类动物和人类中RMSF不同暴露途径的剂量反应模型。 β-泊松模型最适合暴露于气溶胶​​的恒河猴和皮内接种人类的剂量-反应数据（发病率作为反应的终点）。在暴露于（ID50）的人口中，平均50％的感染剂量N50是23个生物体，其95％置信限为1至89个生物体。同样，ID10和ID20分别为2.2和5.0。此外，可以汇总暴露于气溶胶​​的恒河猴和皮内接种人类的数据。这表明适合不同数据集的剂量反应模型没有显着差异，可以用相同的关系描述。

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