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Uncertainty Factor Conundrums: What Lessons Should We Draw?

机译:不确定因素难题:我们应该汲取哪些教训?

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摘要

In "Conundrums with Uncertainty Factors," Cooke has delved into the probabilistic interpretation of uncertainty factors (UFs) and found some significant problems with the conception (or at least with the current conception) of this issue. Over the history of development of what we might call the "UF paradigm," we have made a series of assumptions, definitions, and conceptualizations about contributors to uncertain projections of safe human exposure from animal testing results. These have structured how we conceive of and describe uncertainty in the projection of acceptable intakes. The essence of what Cooke has shown is that all of these suppositions cannot simultaneously be true.
机译:Cooke在“不确定因素难题”中深入研究了不确定因素(UFs)的概率解释,并发现此问题的概念(或至少是当前概念)存在一些重大问题。在所谓的“超滤范式”的发展历史中,我们做出了一系列假设,定义和构想,涉及动物测试结果对人体安全暴露的不确定预测的起因。这些构成了我们如何构想和描述可接受摄入量预测中的不确定性。库克所显示的本质是,所有这些假设不能同时成立。

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  • 来源
    《Risk analysis》 |2010年第3期|349-352|共4页
  • 作者

    Lorenz R. Rhomberg;

  • 作者单位

    Gradient, 20 University Road, Cambridge, MA 02138, USA;

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  • 原文格式 PDF
  • 正文语种 eng
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