Using Physiologically-Based Pharmacokinetic Modeling to Address Nonlinear Kinetics and Changes in Rodent Physiology and Metabolism Due to Aging and Adaptation in Deriving Reference Values for Propylene Glycol Methyl Ether and Propylene Glycol Methyl Ethe

C. R. Kirman; L. M. Sweeney; R. Corley; M. L. Gargas

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Using Physiologically-Based Pharmacokinetic Modeling to Address Nonlinear Kinetics and Changes in Rodent Physiology and Metabolism Due to Aging and Adaptation in Deriving Reference Values for Propylene Glycol Methyl Ether and Propylene Glycol Methyl Ethe

机译：使用基于生理的药代动力学模型来解决由于老化和适应而导致的啮齿动物生理和代谢的非线性动力学和变化，并得出丙二醇甲醚和丙二醇甲醚的参考值

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received little attention in the literature regarding the application of uncertainty factors and interspecies extrapolations to compounds where saturable kinetics occur in the range of the NOAEL. Until such discussions have taken place, reference values based on the former approach are recommended for risk assessments involving human exposures to PGME and PGMEA.

机译：对于不确定性因子和种间外推应用于在NOAEL范围内发生饱和动力学的化合物，文献很少受到关注。在进行此类讨论之前，建议将基于前者方法的参考值用于涉及人类接触PGME和PGMEA的风险评估。

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来源
《Risk analysis》 |2005年第2期|p.271-284|共14页
作者
C. R. Kirman; L. M. Sweeney; R. Corley; M. L. Gargas;
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Sapphire Group, Inc., 2000 Auburn Drive, Suite 200, Beachwood, OH 44122, USA;

tel: 216-514-8430;

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原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
PBPK modeling; propylene glycol methyl ether; reference concentration; reference dose; saturable kinetics;

机译：PBPK模型;丙二醇甲醚;参考浓度;参考剂量;饱和动力学;

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1. Isobaric vapor-liquid equilibria of the binary mixtures propylene glycol methyl ether+ propylene glycol methyl ether acetate, methyl acetate + propylene glycol methyl ether and methanol + propylene glycol methyl ether acetate at 101.3 kPa [J] . Changshen Ye, Xiaolian Dong, Wenjie Zhu, Fluid Phase Equilibria . 2014,第Null期

机译：101.3 kPa下丙二醇甲醚+丙二醇甲醚乙酸酯，乙酸甲酯+丙二醇甲醚和甲醇+丙二醇甲醚乙酸酯的二元混合物的等压气液平衡
2. Vapor–Liquid Equilibrium for the Binary of Propylene Glycol Methyl Ether Acetate + Ethyl Lactate and Propylene Glycol Methyl Ether + Ethyl Lactate at 101.3 and 20.0 kPa [J] . Xusheng Mi, Changsheng Yang, Feizhong Sun, Journal of Chemical and Engineering Data: the ACS Journal for Data . 2021,第1期

机译：用于丙二醇丙二醇甲基醚乙酸乙酯+乙基丙酯和丙二醇丙酯甲醚+乙酯在101.3和20.0kPa下的蒸汽 - 液体平衡
3. Multiphase equilibria of binary and ternary mixtures containing water, propylene glycol methyl ether, and propylene glycol methyl ether propionate [J] . Fluid Phase Equilibria . 2020,第期

机译：二元和三元混合物的多相平衡含水，丙二醇甲基醚和丙二醇甲基醚丙酸酯
4. The effect of materials selection on metals reduction in propylene glycol methyl ether acetate, PGMEA [C] . Majid Entezarian, Bob Geiger Conference on metrology, inspection, and process control for microlithography XXX . 2016

机译：选择材料对丙二醇甲醚乙酸酯，PGMEA中金属还原的影响
5. Simultaneous removal of heavy metal ions and propylene glycol methyl ether by a combined electrochemical and photocatalytic process. [D] . Weli, Amar. 2006

机译：通过组合的电化学和光催化工艺同时去除重金属离子和丙二醇甲醚。
6. Ethylene glycol monomethyl ether and propylene glycol monomethyl ether: metabolism disposition and subchronic inhalation toxicity studies. [O] . R R Miller, E A Hermann, J T Young, 1984

机译：乙二醇单甲醚和丙二醇单甲醚：新陈代谢性状和亚慢性吸入毒性研究。
7. Experimental and kinetic modeling study of the shock tube ignition of a large oxygenated fuel: Tri-propylene glycol mono-methyl ether [O] . Burke, Ultan, Pitz, William J., Curran, Henry J. 2015

机译：大型含氧燃料的冲击管点火的实验和动力学建模研究：三丙二醇单甲醚
8. Chronic Skin Absorption of Propylene Glycol Methyl Ether (33b) and Dipropylene Glycol Methyl Ether (50b) in Rabbits [R] . 2000

机译：家兔丙二醇甲醚（33b）和二丙二醇甲醚（50b）的慢性皮肤吸收

Using Physiologically-Based Pharmacokinetic Modeling to Address Nonlinear Kinetics and Changes in Rodent Physiology and Metabolism Due to Aging and Adaptation in Deriving Reference Values for Propylene Glycol Methyl Ether and Propylene Glycol Methyl Ethe

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