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Estimates of Lifetime-Absorbed Daily Doses from the Use of Personal-Care Products Containing Polyacrylamide: A Monte Carlo Analysis

机译：使用含有聚丙烯酰胺的个人护理产品对生命周期每日吸收剂量的估计：蒙特卡洛分析

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Estimates of the lifetime-absorbed daily dose (LADD) of acrylamide resulting from use of representative personal-care products containing polyacrylamides have been developed. All of the parameters that determine the amount of acrylamide absorbed by an individual vary from one individual to another. Moreover, for some parameters there is uncertainty as to which is the correct or representative value from a range of values. Consequently, the parameters used in the estimation of the LADD of acrylamide from usage of a particular product type (e.g., deodorant, makeup, etc.) were represented by distributions evaluated using Monte Carlo analyses. From these data, distributions of values for key parameters, such as the amount of acrylamide in polyacrylamide, absorption fraction, etc., were defined and used to provide a distribution of LADDs for each personal-care product. The estimated total acrylamide LADD (across all products) for males and females at the median, mean, and 95th percentile of the distribution of individual LADD values were 4.7 x 10~(-8), 2.3 x 10~(-7), and 7.3 x 10~(-7) mg/kg/day for females and 3.6 x 10~(-8), 1.7 x 10~(-7), and 5.4 x 10~(-7) mg/kg/day for males. The ratio of the LADDs to risk-specific dose corresponding to a target risk level of 1 x 10~(-5), the acceptable risk level for this investigation, derived using approaches typically used by the FDA, the USEPA, and proposed for use by the European Union (EU) were also calculated. All ratios were well below 1, indicating that all the extra lifetime cancer risk from the use of polyacrylamide-containing personal-care products, in the manner assumed in this assessment, are well below acceptable levels. Even if it were assumed that an individual used all of the products together, the estimated LADD would still provide a dose that was well below the acceptable risk levels.
机译：已经开发出对使用含有聚丙烯酰胺的代表性个人护理产品所产生的丙烯酰胺终身吸收日剂量（LADD）的估计。决定一个人吸收的丙烯酰胺量的所有参数因一个人而异。此外，对于某些参数，在值范围内，不确定哪个是正确值或代表值。因此，由使用特定产品类型（例如，除臭剂，化妆品等）估算丙烯酰胺的LADD所用的参数由使用蒙特卡洛分析评估的分布表示。根据这些数据，定义了关键参数值的分布，例如聚丙烯酰胺中丙烯酰胺的量，吸收率等，并用于提供每种个人护理产品的LADD分布。在各个LADD值分布的中位数，平均值和第95个百分位数处，男性和女性的估计总丙烯酰胺LADD（适用于所有产品）分别为4.7 x 10〜（-8），2.3 x 10〜（-7）和女性为7.3 x 10〜（-7）mg / kg /天，男性为3.6 x 10〜（-8），1.7 x 10〜（-7）和5.4 x 10〜（-7）mg / kg /天。 LADDs与特定于目标风险水平1 x 10〜（-5）的风险特定剂量之比，即本研究可接受的风险水平，使用FDA，USEPA通常采用的方法得出，并建议使用还由欧盟（EU）进行了计算。所有比率均远低于1，表明按照该评估中假定的方式，使用含聚丙烯酰胺的个人护理产品引起的所有终生癌症风险均远低于可接受水平。即使假定一个人一起使用了所有产品，估计的LADD仍将提供远低于可接受风险水平的剂量。

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