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Mesothelioma Among Brake Mechanics: An Expanded Analysis of a Case-Control Study

机译：间皮瘤在制动力学中：病例对照研究的扩展分析

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The U.S. Environmental Protection Agency has begun discussions to consider its assessment of asbestos toxicity related to mineral form and fiber size. Brake workers are typically exposed to short chrysotile fibers. To explore the mesothelioma risk among brake workers, considering other occupational exposures to asbestos, data from a study that was published previously were obtained and the analysis was extended. The National Cancer Institute provided data from a case-control study of mesothelioma. Because many participants with a history of brake work also had employment in other asbestos-related occupations, mesothelioma cases and controls were compared for a history of brake work, controlling for employment in eight occupations with potential asbestos exposure. A stratified analysis was also performed excluding those with any of the eight occupations. Possible interactions between brake work and other occupational exposures related to risk of mesothelioma were also examined. The odds ratio (OR) for employment in brake installation or repair was 0.71 (95% CI: 0.30-1.60) when controlled for insulation or shipbuilding. When a history of employment in any of the eight occupations with potential asbestos exposure was controlled, the OR was 0.82 (95% CI: 0.36-1.80). ORs did not increase with increasing duration of brake work. Exclusion of those with any of the eight exposures resulted in an OR of 0.62 (95% CI: 0.01-4.71) for occupational brake work. There was no evidence of an interaction between brake work and other occupational exposures. These latter analyses were based on small numbers of exposed cases. The results are consistent with the existing literature indicating that brake work does not increase the risk of mesothelioma and adds to the evidence that fiber type and size are important determinants of mesothelioma risk.
机译：美国环境保护局已经开始讨论，以考虑评估与矿物形态和纤维尺寸有关的石棉毒性。制动工人通常会接触到温石棉短纤维。为了探讨制动工人之间的间皮瘤风险，考虑其他职业对石棉的接触，从先前发表的一项研究中获得了数据，并进行了分析。美国国家癌症研究所提供了间皮瘤病例对照研究的数据。由于许多具有制动工作历史的参与者也曾从事过其他与石棉有关的职业，因此将间皮瘤病例和对照进行了制动工作的历史比较，以控制八种可能接触石棉的职业中的就业。还进行了分层分析，排除了八个职业中的任何一个。还检查了制动工作与其他与间皮瘤风险相关的职业接触之间的可能相互作用。受绝缘或造船控制时，安装或维修制动器的比值比（OR）为0.71（95％CI：0.30-1.60）。当控制了八种可能接触石棉的职业的工作经历时，OR为0.82（95％CI：0.36-1.80）。 OR并没有随着制动时间的增加而增加。排除八种暴露中的任何一种，导致职业制动工作的OR值为0.62（95％CI：0.01-4.71）。没有证据表明制动工作与其他职业暴露之间存在相互作用。后面的这些分析是基于少量的暴露病例。结果与现有文献一致，该文献表明制动工作不会增加间皮瘤的风险，并增加了纤维类型和大小是间皮瘤风险的重要决定因素的证据。

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