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首页> 外文期刊>Russian journal of marine biology >The Effect of Pentacyclic Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Lambe, 1894 on the Activity of Natural β-1,3-D-glucanase from the Marine Fungus Chaetomium indicum Cord a, 1840 and the Marine Bivalve Mollusk Spisula sachalinensis, Schrenck, 1861
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The Effect of Pentacyclic Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Lambe, 1894 on the Activity of Natural β-1,3-D-glucanase from the Marine Fungus Chaetomium indicum Cord a, 1840 and the Marine Bivalve Mollusk Spisula sachalinensis, Schrenck, 1861

机译：1894年海洋海绵Monanchora pulchra Lambe的五环胍生物碱对海洋真菌印度小球藻a，1840年和海洋双壳软体动物Spisula sachalinensis，Schrenck和1861年天然β-1,3-D-葡聚糖酶活性的影响

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摘要

The effect of pentacyclic guanidine alkaloids monanchomycalin B, monanchocidin A and normonanchocidin A isolated from the Far-Eastern marine sponge Monanchora pulchra was investigated towards the activity of exo-beta-1,3-D-glucanase from the filamentous marine fungus Chaetomium indicum and endo-beta-1,3-D-glucanase L-IV from the marine bivalve mollusk Spisula sachalinensis. All compounds were shown to be slow irreversible inhibitors of exo-beta-1,3-D-glucanase and significantly activated endo-beta-1,3-Dglucanase. The equilibrium inhibition constants (K (i), mu M) and the inactivation rate constants (k (inact), min(-1)) were determined for each compound. The inhibitory capacities of alkaloids were shown to depend on the structure of the "anchor" part of the molecule of the compounds. Normonanchocidin A was the best inhibitor of exo-beta-1,3-D-glucanase from fungi. A possible biological role of these compounds in the life of sponges and their microbial symbionts is discussed here.
机译：研究了从远东海洋海绵Monanchora pulchra分离得到的五环胍生物碱monanchomycalin B，monanchocidin A和normonanchocidin A对丝状海洋真菌Chaetomium indicum和endo的外切β-1,3-D-葡聚糖酶活性的影响。来自海洋双壳贝类软体动物螺旋藻的-β-1,3-D-葡聚糖酶L-IV。所有化合物均显示为exo-β-1,3-D-葡聚糖酶的缓慢不可逆抑制剂和显着活化的beta-1,3-D-葡聚糖内切酶。确定每种化合物的平衡抑制常数（K（i），μM）和失活速率常数（k（inact），min（-1））。已显示生物碱的抑制能力取决于化合物分子的“锚”部分的结构。 Normonanchocidin A是真菌中exo-beta-1,3-D-葡聚糖酶的最佳抑制剂。本文讨论了这些化合物在海绵及其微生物共生物中的可能生物学作用。

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