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首页> 外文期刊>Russian journal of marine biology >Preparation, Properties and Biological Applications of Water Soluble Chitin Oligosaccharides from Marine Organisms
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Preparation, Properties and Biological Applications of Water Soluble Chitin Oligosaccharides from Marine Organisms

机译：海洋生物水溶性甲壳质寡糖的制备，性质及生物学应用

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摘要

Chitin oligosaccharides (COSs) can be isolated from various natural resources, which have widely been used in biological active supplements (BAS) for the benefit of humankind. Several technological approaches for the preparation of COSs such as enzymatic, chemical, acid-catalysts hydrolysis, microwave radiation, membrane bioreactor methods have been developed and among them, membrane bioreactor, bio-conversion and continuous mass production technologies are reported to be excellent. Compounds isolated from natural products have made a drastic impact on the pharmaceutical industry and especially, water-soluble chitin oligosaccharides have shown greater clinical activity, which ha ve been demonstrated in various cell lines of disease significance. The activities of these COSs were being investigated in different patients, animals and even plants as a broad phase clinical trial program. In the present article, we have discussed the COSs preparation by different methods through comprehensive diffraction procedures along with the merits and demerits given in detail. In addition, a summary of recent work describing the synthesis and biological activities of water-soluble COSs has been presented here.
机译：几丁质低聚糖（COSs）可以从各种自然资源中分离出来，而这些自然资源已广泛用于人类的生物活性补品（BAS）中。已经开发了几种制备COS的技术方法，例如酶促，化学，酸催化剂水解，微波辐射，膜生物反应器方法，其中据报道膜生物反应器，生物转化和连续批量生产技术是极好的。从天然产物中分离的化合物对制药业产生了巨大的影响，尤其是水溶性几丁质寡糖已显示出更大的临床活性，已在各种具有重要疾病意义的细胞系中得到证实。这些COS的活性已在广泛的临床试验计划中针对不同的患者，动物甚至植物进行了研究。在本文中，我们讨论了通过综合衍射程序通过不同方法制备COSs的优缺点。另外，这里介绍了描述水溶性COSs合成和生物学活性的最新工作的摘要。

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  • 来源
    《Russian journal of marine biology》 |2012年第4期|p.351-358|共8页
  • 作者

    A. B. A. Ahmed; Rosna Mat Taha; Sadegh Mohajer; M. Elnaiem Elaagib; Se Kwon Kim;

  • 作者单位

    Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia,Marine Bioprocess Research Center, Department of Chemistry, Pukyong National University, Busan, South Korea;

    Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia;

    Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia;

    Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia;

    Marine Bioprocess Research Center, Department of Chemistry, Pukyong National University, Busan, South Korea;

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  • 正文语种 eng
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  • 关键词

    chitin oligosaccharides; enzymatic hydrolysis; membrane bioreactor; cell lines; biological activity;

    机译：几丁质低聚糖;酶促水解;膜生物反应器细胞系;生物活性;

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