Heterogeneity of Nucleoside Kinases in Marine Microorganism Cells

Yu. A. Nemtseva; N. A. Terenteva; L. L. Terentev; L. S. Shevchenko; V. V. Mikhailov; V. A. Rasskazov

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Heterogeneity of Nucleoside Kinases in Marine Microorganism Cells

机译：海洋微生物细胞中核苷激酶的异质性

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The incorporation of [~3H]-thymidine and [~3H]-uridine into nucleic acids of six marine microorganism strains belonging to different genera was studied. It was shown that the radioactive label of each of those exogenous precursors could be included into both the DNA and the RNA of bacterial cells. The activity of the nucleoside phosphorylation enzymes—thymidine and uridin kinases—was defined in bacterial cell extracts. The activity of thymidine kinase in the extracts is noticeably higher than the activity of uridine kinase, this enzyme, unlike uridine kinase, being present in all marine bacteria strains studied. After the partial purification of phosphorylation enzymes by means of ion-exchange chromatography, a number of enzymatic properties of nucleoside kinases and their substrate specificity were investigated. It was shown that the set of precursor phosphorylation enzymes in the strains under study differed in representatives of different marine bacterial genera. marine microorganisms, bacteria, thymidine and uridine incorporation, thymidine kinase, thymi-

机译：研究了[〜3H]-胸腺嘧啶核苷和[〜3H]-尿苷掺入六个属于不同属的海洋微生物菌株的核酸。结果表明，这些外源性前体中的每一种的放射性标记都可以包含在细菌细胞的DNA和RNA中。细菌细胞提取物中已确定了核苷磷酸化酶（胸苷和尿苷激酶）的活性。提取物中的胸苷激酶活性明显高于尿苷激酶活性，该酶与尿苷激酶不同，存在于所有研究的海洋细菌菌株中。在通过离子交换色谱法部分纯化磷酸化酶之后，研究了核苷激酶的许多酶学性质及其底物特异性。结果表明，所研究菌株中的前体磷酸化酶的集合在不同海洋细菌属的代表中有所不同。海洋微生物，细菌，胸苷和尿苷的掺入，胸苷激酶，胸腺嘧啶

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来源
《Russian journal of marine biology》 |2006年第1期|p.55-63|共9页
作者
Yu. A. Nemtseva; N. A. Terenteva; L. L. Terentev; L. S. Shevchenko; V. V. Mikhailov; V. A. Rasskazov;
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Pacific Institute of Bioorganic Chemistry, Far East Division, Russian Academy of Sciences, Vladivostok, 690022 Russia;

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正文语种 eng
中图分类生物科学;
关键词
dilate kinase; uridine kinase.;

机译：扩张激酶;尿苷激酶。;

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1. Inhibition of nucleoside diphosphate kinase activity by in vitro phosphorylation by protein kinase CK2 Differential phosphorylation of NDP kinases in HeLa cells in culture [J] . Biondi Ricardo M., Engel Matthias, Issinger Olaf-G., FEBS Letters . 1996,第1a2期

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2. Inhibition of nucleoside diphosphate kinase activity by in vitro phosphorylation by protein kinase CK2 Differential phosphorylation of NDP kinases in HeLa cells in culture [J] . Biondi Ricardo M., Engel Matthias, Issinger Olaf-G., FEBS Letters . 1996,第1a2期

机译：蛋白激酶CK2体外磷酸化抑制核苷二磷酸激酶活性培养基中培养的HeLa细胞中NDP激酶的差异磷酸化
3. Selective Phosphorylation of South and North-Cytidine and Adenosine Methanocarba-Nucleosides by Human Nucleoside and Nucleotide Kinases Correlates with Their Growth Inhibitory Effects on Cultured Cells [J] . Sjuvarsson Elena, Marquez Victor E., Eriksson Staffan Nucleosides, nucleotides and nucleic acids . 2015,第7a9期

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5. Pharmacologic induction of Epstein-Barr virus kinases: Sensitivity of kinase-expressing cells to nucleoside analogues. [D] . Moore, Stacy Mihalik. 2000

机译：爱泼斯坦-巴尔病毒激酶的药理诱导：激酶表达细胞对核苷类似物的敏感性。
6. The maximum activities of hexokinase phosphorylase phosphofructokinase glycerol phosphate dehydrogenases lactate dehydrogenase octopine dehydrogenase phosphoenolpyruvate carboxykinase nucleoside diphosphatekinase glutamate-oxaloacetate transaminase and arginine kinase in relation to carbohydrate utilization in muscles from marine invertebrates. [O] . V A Zammit, E A Newsholme 1976

机译：己糖激酶磷酸化酶磷酸果糖激酶甘油磷酸脱氢酶乳酸脱氢酶章鱼碱脱氢酶磷酸烯醇丙酮酸羧激酶核苷二磷酸激酶谷氨酸-草酰乙酸转氨酶和精氨酸激酶在肌肉中碳水化合物利用方面的最大活性。
7. Inhibition of nucleoside diphosphate kinase activity by in vitro phosphorylation by protein kinase CK2 Differential phosphorylation of NDP kinases in HeLa cells in culture [O] . Biondi Ricardo M., Engel Matthias, Sauane Moira, 1996

机译：蛋白激酶CK2体外磷酸化抑制核苷二磷酸激酶活性培养基中培养的HeLa细胞中NDP激酶的差异磷酸化
8. Both CD28 Ligands CD8O (B7-l) and CD86 (B7-2) Activate Phosphatidylinosito 3-Kinase, and Wortmannin Reveals Heterogeneity in the Regulation of T Cell IL-2 Secretion [R] . Ueda, Y., Levine, B. L., Huang, M. L., 1995

机译：CD28配体CD8O（B7-1）和CD86（B7-2）均激活磷脂酰肌醇3-激酶，Wortmannin显示调节T细胞IL-2分泌的异质性

Heterogeneity of Nucleoside Kinases in Marine Microorganism Cells

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