Peptide Modulators of ASIC Channels of the Sea Anemone Urticina aff. coriacea (Cuvier, 1798) from the Sea of Okhotsk

Gladkikh I. N.; Kvetkina A. N.; Kostina E. E.; Kalina R. S.; Grebnev B. B.; Koshelev S. G.; Kozlov S. A.; Monastyrnaya M. M.; Kozlovskaya E. P.

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Peptide Modulators of ASIC Channels of the Sea Anemone Urticina aff. coriacea (Cuvier, 1798) from the Sea of Okhotsk

机译：海葵荨麻疹的ASIC通道的肽调节剂。鄂霍次克海的（居维叶，1798年）

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A search for biologically active peptides has been performed in an aqueous extract of the sea anemone Urticina aff. coriacea (Cuvier, 1798) (Actiniidae) from the Sea of Okhotsk. A separation of the peptides by size-exclusion chromatography and subsequent electrophysiological testing have shown that peptides of three fractions can completely inhibit currents of mammalian ASIC1a channels. The sea anemone Urticina aff. coriacea is believed to be a promising source of novel peptides that interact with ASIC channels.

机译：已经在海葵荨麻疹aff的水提取物中进行了生物活性肽的搜索。鄂霍次克海的coriacea（Cuvier，1798年）（Actiniidae）。通过大小排阻色谱分离肽和随后的电生理测试表明，三部分的肽可以完全抑制哺乳动物ASIC1a通道的电流。海葵Urticina aff。据信草是与ASIC通道相互作用的新型肽的有希望的来源。

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《Russian journal of marine biology》 |2018年第6期|458-464|共7页
作者
Gladkikh I. N.; Kvetkina A. N.; Kostina E. E.; Kalina R. S.; Grebnev B. B.; Koshelev S. G.; Kozlov S. A.; Monastyrnaya M. M.; Kozlovskaya E. P.;
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作者单位

Russian Acad Sci Elyakov Pacific Inst Bioorgan Chem Far East Branch Vladivostok 690022 Russia;

Russian Acad Sci Zhirmunsky Inst Marine Biol Natl Sci Ctr Marine Biol Far East Branch Vladivostok 690041 Russia;

Russian Acad Sci Shemyakin Ovchinnikov Inst Bioorgan Chem Moscow 117997 Russia;

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正文语种 eng
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关键词
sea anemone; peptides; modulators of ASIC channels;

机译：海葵;肽;ASIC通道的调制器;

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1. New APETx-like peptides from sea anemone Heteractis crispa modulate ASIC1a channels [J] . Kalina Rimma, Gladkikh Irina, Dmitrenok Pavel, Peptides: An International Journal . 2018,第期

机译：来自海洋藻藻糖异相脆饼Crispa调制ASIC1A通道的新型Apetx样肽
2. APETx-Like Peptides from the Sea Anemone Heteractis crispa , Diverse in Their Effect on ASIC1a and ASIC3 Ion Channels [J] . Rimma S. Kalina, Sergey G. Koshelev, Elena A. Zelepuga, Toxins . 2020,第4期

机译：海葵异源神经糖蛋白酶蛋白酶蛋白酶蛋白酶蛋白酶蛋白质，对ASIC1A和ASIC3离子通道的影响多样化
3. Novel sea anemone peptide inhibitor of acid-sensing ion channel 3 (ASIC3) [J] . Osmakov D., Andreev Y. A., Koshelev S. G., The FEBS journal . 2014,第Suppla1期

机译：酸感应离子通道3（ASIC3）的新型海葵肽抑制剂
4. Isolation of Novel Peptide Toxins From the Sea Anemone Actinostephanus haeckeli [C] . Tomohiro Honma, Emiko Nagashima, Hideo Tsukamoto Japanese peptide symposium . 2010

机译：来自海洋莲酮的新型肽毒素的分离acemostephanus haeckeli
5. The Effects of Sea Level Rise and Nest Location on Reproductive Success in Leatherback (Dermochelys coriacea) and Green ( Chelonia mydas) Sea Turtles on Bioko Island, Equatorial Guinea [D] . Veelenturf, Callie Annette. 2017

机译：赤道几内亚比奥科岛上海平面上升和筑巢位置对棱皮海龟（Dermochelys coriacea）和绿海龟（Chelonia mydas）海龟繁殖成功的影响
6. APETx-Like Peptides from the Sea Anemone Heteractis crispa Diverse in Their Effect on ASIC1a and ASIC3 Ion Channels [O] . Rimma S. Kalina, Sergey G. Koshelev, Elena A. Zelepuga, 2020

机译：来自海葵Heteractis crispa的APETx样肽它们对ASIC1a和ASIC3离子通道的作用各不相同
7. Sea Anemone Peptide with Uncommon β-Hairpin Structure Inhibits Acid-sensing Ion Channel 3 (ASIC3) and Reveals Analgesic Activity [O] . Dmitry I. Osmakov, Sergey A. Kozlov, Yaroslav A. Andreev, 2013

机译：海葵肽具有罕见的β-发夹结构抑制酸感测离子通道3（ASIC3）并揭示镇痛活性

Peptide Modulators of ASIC Channels of the Sea Anemone Urticina aff. coriacea (Cuvier, 1798) from the Sea of Okhotsk

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